Anti-TNF-alpha loss of response is associated with a decreased percentage of FoxP3+ T cells and a variant NOD2 genotype in patients with Crohn’s disease

被引：0

作者：

Oriol Juanola

Alba Moratalla

Ana Gutiérrez

Laura Sempere

Pedro Zapater

Paula Giménez

Isabel Almenta

Gloria Peiró

José M. González-Navajas

José F. Such

Rubén Francés

机构：

[1] CIBERehd,Servicio de Medicina Digestiva

[2] Instituto de Salud Carlos III,Servicio de Farmacología Clínica

[3] Hospital General Universitario de Alicante,Servicio de Anatomía Patológica

[4] Hospital General Universitario de Alicante,Dpto. Medicina Clínica

[5] Hospital General Universitario de Alicante,Digestive Disease Institute

[6] Universidad Miguel Hernández,undefined

[7] Cleveland Clinic Abu Dhabi,undefined

来源：

Journal of Gastroenterology | 2015年 / 50卷

关键词：

Crohn’s disease; FoxP3+ regulatory T cells; Anti-TNF-alpha;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

页码：758 / 768

页数：10

共 25 条

[1] Anti-TNF-alpha loss of response is associated with a decreased percentage of FoxP3+T cells and a variant NOD2 genotype in patients with Crohn's disease
Juanola, Oriol
Moratalla, Alba
Gutierrez, Ana
Sempere, Laura
Zapater, Pedro
Gimenez, Paula
Almenta, Isabel
Peiro, Gloria
Gonzalez-Navajas, Jose M.
Such, Jose F.
Frances, Ruben
JOURNAL OF GASTROENTEROLOGY, 2015, 50 (07) : 758 - 768
[2] Variants in NOD2 genotype are associated with decreased numbers of foxp3+ T cells in both the periphery and lamina propria of patients with Crohn's disease (CD)
Rahman, Meher
Smyrk, Thomas C.
Svingen, Phyllis A.
Lord, James D.
Faubion, William A.
GASTROENTEROLOGY, 2007, 132 (04) : A669 - A669
[3] Anti-TNF-Alpha Therapy Is Associated With an Increased Expression of Regulatory T Cells in Blood of Patients With Crohn's Disease
Moratalla, Alba
Gutierrez, Ana
Sempere, Laura
Zapater, Pedro
Almenta, Isabel M.
Gonzalez-Navajas, Jose M.
Such, Jose
Frances, Ruben
GASTROENTEROLOGY, 2014, 146 (05) : S648 - S648
[4] ANTI-TNF-ALPHA THERAPY IS ASSOCIATED WITH AN INCREASED EXPRESSION OF REGULATORY T CELLS IN BLOOD OF PATIENTS WITH CROHN'S DISEASE
Moratalla, A.
Gutierrez, A.
Sempere, L.
Zapater, P.
Almenta, I.
Gonzalez-Navajas, J.
Such, J.
Frances, R.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2014, 115 : 286 - 287
[5] NOD2 AND ATG16 L1 ARE ASSOCIATED WITH ANTI-TNF TROUGH LEVELS IN A COHORT OF PATIENTS WITH CROHN'S DISEASE
Almenara, S.
Egoavil, C. M.
Londono, A. C.
Gutierrez, A.
Sempere, L.
Zapater, P.
Cameo, J., I
Gonzalez-Navajas, J.
Frances, R.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2018, 123 : 94 - 95
[6] Anti tumour necrosis-α therapy increases the number of FOXP3+ regulatory T cells in children affected by Crohn's disease
Ricciardelli, Ida
Lindley, Keith J.
Londei, Marco
Quaratino, Sonia
IMMUNOLOGY, 2008, 125 (02) : 178 - 183
[7] T2 enhances in situ level of Foxp3+ regulatory cells and modulates inflammatory cytokines in Crohn's disease
Li, Guanwei
Ren, Jianan
Wang, Gefei
Gu, Guosheng
Hu, Dong
Ren, Huajian
Hong, Zhiwu
Wu, Xiuwen
Liu, Song
Li, Jieshou
INTERNATIONAL IMMUNOPHARMACOLOGY, 2014, 18 (02) : 244 - 248
[8] TNFα and IL-10 release according to the CARD15/NOD2 genotype in peripheral blood monocytes from patients with Crohn's disease
Torok, HP
Glas, J
Schaaf, A
Wagner, S
Ochsenkuehn, T
Lohse, P
Mussack, T
Folwaczny, C
GASTROENTEROLOGY, 2004, 126 (04) : A104 - A104
[9] Clinical improvement in Crohn's disease (CD) patients treated with anti-TNF-alpha correlates with downregulated mucosal T helper 1 responses.
Plevy, SE
Carramanzana, NM
Deem, RL
Woody, JN
Targan, SR
GASTROENTEROLOGY, 1996, 110 (04) : A993 - A993
[10] Decreased mucosal expression of the E3 ubiquitin ligase, Pellino3, a mediator of NOD2, in a cohort of patients with Crohn's disease
Hall, B.
Holleran, G.
Yang, S.
Wang, B.
Humphries, F.
Jackson, R.
Healy, M. E.
Bergin, R.
McNamara, D.
Moynagh, P.
IRISH JOURNAL OF MEDICAL SCIENCE, 2015, 184 : S24 - S24

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