Maternal antibodies and developing blood-brain barrier

被引：29

作者：

Kowal, Czeslawa ^{[1
]}

Athanassiou, Andrew ^{[1
]}

Chen, Huiyi ^{[1
]}

Diamond, Betty ^{[1
,2
]}

机构：

[1] Feinstein Inst Med Res, Ctr Autoimmune & Musculoskeletal Dis, Manhasset, NY 11030 USA

[2] Hofstra North Shore LIJ Sch Med, Hempstead, NY 11549 USA

来源：

IMMUNOLOGIC RESEARCH | 2015年 / 63卷 / 1-3期

关键词：

Autoimmunity; Neuroimmunology; Maternal antibodies; Developing blood-brain barrier; GLUTAMATE-RECEPTOR ANTIBODIES; CONGENITAL HEART-BLOCK; NEONATAL LUPUS; AUTOIMMUNE-DISEASES; CEREBROSPINAL-FLUID; AUTISM; MOTHERS; IGG; AUTOANTIBODIES; CHILDREN;

D O I：

10.1007/s12026-015-8714-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We briefly review the protective role of maternal antibodies during fetal development and at early postnatal stages. We describe antibody delivery to fetuses, particularly in the context of the developing blood-brain barrier (BBB), and present the essential concepts regarding the adult BBB, together with existing information on the prenatal developing BBB. We focus on maternal antibody transfer to the developing brain and the consequences of the presence of pathogenic antibodies at early stages of brain development on subsequent brain dysfunction.

引用

页码：18 / 25

页数：8

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