The Possibility of Cytochrome P450 1A1/1A2 Induction in Cells of Distant Lymph Nodes of Rats after Enteral Treatment with Benzo[a]pyrene

被引：0
|
作者：
Yu. I. Borodin
I. V. Maiborodin
A. F. Safina
D. N. Strunkin
机构：
[1] Russian Academy of Medical Sciences,Institute of Clinical and Experimental Lymphology, Siberian Division
来源：
Bulletin of Experimental Biology and Medicine | 2005年 / 140卷
关键词：
cytochrome P450; benzo[a]pyrene; lymph nodes; macrophages; endotheliocytes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The mesenteric, mediastinal, and popliteal lymph nodes of rats were studied by indirect immunoperoxidase method using monoclonal antibodies to cytochrome P450 1A1/1A2 after oral treatment with benzo[a]pyrene. These cytochrome forms were detected in monocytes, macrophages, reticular and littoral cells, cell detritus, and liquid contents of the paracortical and medullary sinuses of all studied lymph nodes. The results indicate that exo- and endogenous toxic substances are oxidized not only in the liver, but also in lymph nodes.
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页码：564 / 567
页数：3
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