Differentiation of human and murine induced pluripotent stem cells to microglia-like cells

被引：0

作者：

Hetal Pandya

Michael J Shen

David M Ichikawa

Andrea B Sedlock

Yong Choi

Kory R Johnson

Gloria Kim

Mason A Brown

Abdel G Elkahloun

Dragan Maric

Colin L Sweeney

Selamawit Gossa

Harry L Malech

Dorian B McGavern

John K Park

机构：

[1] National Institute of Neurological Disorders and Stroke,

[2] National Institutes of Health,undefined

[3] National Human Genome Research Institute,undefined

[4] National Institutes of Health,undefined

[5] National Institute of Allergy and Infectious Diseases,undefined

[6] National Institutes of Health,undefined

[7] Santa Barbara Neuroscience Institute,undefined

来源：

Nature Neuroscience | 2017年 / 20卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Pandya et al. describe a protocol to differentiate human and mouse iPSCs into cells with the phenotype, transcriptional profile and functional properties of microglia. The treatment of murine intracranial malignant gliomas with these cells demonstrates their potential clinical use. These microglia-like cells will enable further studies into the role of microglia in health and disease.

引用

页码：753 / 759

页数：6

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