Inhibition of mitochondrial protein import by mutant huntingtin

被引：0

作者：

Hiroko Yano

Sergei V Baranov

Oxana V Baranova

Jinho Kim

Yanchun Pan

Svitlana Yablonska

Diane L Carlisle

Robert J Ferrante

Albert H Kim

Robert M Friedlander

机构：

[1] Neuroapoptosis Laboratory,Department of Neurological Surgery

[2] University of Pittsburgh,Department of Neurological Surgery

[3] Washington University School of Medicine,Department of Neurology

[4] Washington University School of Medicine,Department of Genetics

[5] Washington University School of Medicine,Department of Developmental Biology

[6] Washington University School of Medicine,undefined

[7] University of Pittsburgh Medical Center,undefined

来源：

Nature Neuroscience | 2014年 / 17卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Mitochondrial dysfunction has been associated with Huntington's disease. The authors show that mutant huntingtin binds to the mitochondrial import protein TIM23, leading to a deficit in import. Overexpression of TIM23 subunits partially rescued the import defect and subsequent neuronal death.

引用

页码：822 / 831

页数：9

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