Hypergravity affects morphology and function in microvascular endothelial cells

被引：0
|
作者：
Monica Monici
Nicola Marziliano
Venere Basile
Giovanni Romano
Antonio Conti
Silvia Pezzatini
Lucia Morbidelli
机构：
[1] University of Florence,CEO
[2] San Matteo Hospital, Center of Excellence in Optronics c/o Dep. of Clinical Physiopathology
[3] University of Florence,IRCCF
[4] Dept. Molecular Biology University of Siena,Dept. of Clinical Physiopathology
来源：
Microgravity - Science and Technology | 2006年 / 18卷
关键词：
Flavin; Microvascular Endothelial Cell; Cytoskeleton Organization; Cell Energy Metabolism; Human Primary Endothelial Cell;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cardiovascular diseases are major health problems in astronauts and pilots. The basic problem in cardiovascular diseases is the loss of function by vascular endothelium. It has been demonstrated that changes in inertial conditions (i.e. hypo- and hypergravity) can affect both phenotypic and genotypic expression in endothelial cells. This report describes the effects observed in endothelial cells from coronary post-capillary venules after repeated exposures to hypergravity conditions, alternating with recovery periods. The results showed changes in gene expression, cell energy metabolism, morphology and cytoskeleton organization.
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页码：234 / 238
页数：4
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