Can Co(II) or Cd(II) substitute for Zn(II) in zinc fingers?

被引：0
|
作者：
P Rabindra Reddy
M Radhika
机构：
[1] Osmania University,Department of Chemistry
来源：
Journal of Chemical Sciences | 2001年 / 113卷 / 1期
关键词：
Zinc finger; cobalt; cadmium; cysteine methylester; histidine methylester; stability constants; thermodynamic parameters;
D O I：
10.1007/BF02708550
中图分类号：
学科分类号：
摘要：
Zinc finger domains consist of sequences of amino acids containing cysteine and histidine residues tetrahedrally coordinated to a zinc ion. The role of zinc in a DNA binding finger was considered purely structural due to the absence of redox chemistry in zinc. However, whether other metals e.g. Co(II) or Cd(II) can substitute Zn(II) is not settled. For an answer the detailed interaction of Co(II) and Cd(II) with cysteine methylester and histidine methylester has been investigated as a model for the zinc core in zinc fingers. The study was extended to different temperatures to evaluate the thermodynamic parameters associated with these interactions. The results suggest that zinc has a unique role.
引用
收藏
页码：35 / 42
页数：7
相关论文
共 50 条
  • [31] PHYSICOCHEMICAL STUDIES OF NI(II), CO(II), ZN(II), AND CD(II) IONS WITH P-FLUOROBENZOYLACETONE
    BACHLAS, BP
    RAI, AK
    GUPTA, BP
    MONATSHEFTE FUR CHEMIE, 1977, 108 (01): : 41 - 49
  • [32] MIXED-LIGAND COMPLEXES OF CO(II), CU(II), ZN(II), CD(II) AND HG(II) WITH ACETOACETANILIDE AND ISOQUINOLINE
    MAHAPATRA, BB
    DAS, DK
    INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 1987, 26 (02): : 173 - 174
  • [33] CO(II), NI(II), CU(II), ZN(II), AND CD(II), CHELATES WITH MALONIC HYDRAZIDE AND ITS ARYLIDENE DERIVATIVES
    ISSA, RM
    TEMERK, YM
    MAHMOUD, MR
    KHATTAB, MA
    MONATSHEFTE FUR CHEMIE, 1976, 107 (02): : 485 - 493
  • [34] SYNTHESIS AND STRUCTURAL STUDIES OF COMPLEXES OF CO(II), NI(II), CU(II), ZN(II) AND CD(II) WITH SUBSTITUTED CHALCONES
    RAO, TS
    REDDY, KL
    LINGAIAH, P
    PROCEEDINGS OF THE INDIAN ACADEMY OF SCIENCES-CHEMICAL SCIENCES, 1988, 100 (05): : 363 - 373
  • [35] STABILITIES OF CHELATES OF 2-PHENYLACETOHYDROXAMIC ACID WITH CU(II), NI(II), ZN(II), CO(II), MN(II) AND CD(II)
    REDDY, D
    SETHURAM, B
    RAO, TN
    INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 1976, 14 (01): : 67 - 68
  • [36] POLYMETALLIC COMPLEXES .15. AZODYE COMPLEXES OF CO(II), NI(II), CU(II), ZN(II), CD(II) AND HG(II)
    MAHAPATRA, BB
    PATEL, BK
    SATPATHY, KC
    ACTA CHIMICA HUNGARICA-MODELS IN CHEMISTRY, 1989, 126 (02): : 207 - 211
  • [37] Studies on the complexes of Cu(II), Ni(II), Co(II), Mn(II), Zn(II), Cd(II) with the isonicotinoylhydrazone-3-aldehydeindole
    Mitu, Liviu
    Kriza, Angela
    Dianu, Mariana
    ASIAN JOURNAL OF CHEMISTRY, 2008, 20 (02) : 1627 - 1632
  • [38] THERMAL-DECOMPOSITION OF CO(II), NI(II), CU(II), ZN(II), CD(II) AND PB(II) PARA-TOLUENESULFONATES
    BOMBIN, M
    GUERRERO, A
    MARTINEZZAPORTA, MA
    RAMIREZ, A
    JEREZ, A
    THERMOCHIMICA ACTA, 1989, 146 : 341 - 352
  • [39] COMPLEXES OF CO(II), NI(II), CU(II), ZN(II), CD(II) AND HG(II) WITH CHELATING BIDENTATE SCHIFF-BASE
    MAHAPATRA, BB
    MAHAPATRA, SM
    PUJARI, SK
    CHIRANJEEVI, A
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1982, 59 (08) : 988 - 989
  • [40] STUDIES ON THIOCYANATE AND CYANATE COMPLEXES OF MN(II), FE(II), CO(II), NI(II), CU(II), ZN(II), CD(II), HG(II) AND PD(II)
    SINGH, PP
    KHAN, SA
    INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 1976, 14 (03): : 176 - 178
12345