Association of MICA-129Met/Val polymorphism with clinical outcome of anti-TNF therapy and MICA serum levels in patients with rheumatoid arthritis

被引:0
|
作者
Milena Iwaszko
Jerzy Świerkot
Marta Dratwa
Barbara Wysoczańska
Lucyna Korman
Bartosz Bugaj
Katarzyna Kolossa
Sławomir Jeka
Piotr Wiland
Katarzyna Bogunia-Kubik
机构
[1] Polish Academy of Sciences,Laboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy
[2] Wrocław Medical University,Department of Rheumatology and Internal Medicine
[3] UMK,Jan Biziel University Hospital No. 2, Department of Rheumatology and Connective Tissue Diseases, Bydgoszcz, Collegium Medicum in Bydgoszcz
来源
The Pharmacogenomics Journal | 2020年 / 20卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
MHC class I polypeptide-related sequence A (MICA) is a stress-induced protein involved in activation of NK and T cells through interaction with NKG2D receptor. These molecules are atypically expressed in synovium of patients diagnosed with rheumatoid arthritis (RA). A total of 279 patients with RA, qualified to TNF-blockade therapy, were genotyped for MICA rs1051792 SNP. The effectiveness of anti-TNF agents was assessed with European League Against Rheumatism criteria. Significant relationship between MICA rs1051792 and outcome of TNF-blockade therapy has been found. The MICA rs1051792 GG genotype was overrepresented in patients non-responsive to anti-TNF drugs in comparison with other genotypes (p = 0.010). On the other hand, beneficial therapeutic response was more frequently detected among RA subjects possessing heterozygous genotype than those with homozygous genotypes (p = 0.003). Furthermore, increased MICA concentrations in serum were observed in patients possessing MICA rs1051792 GG genotype as compared with those with GA or AA genotypes (p = 1.8 × 10−5). The results from this study indicate the potential influence of MICA rs1051792 polymorphism on modulation of therapeutic response to TNF-blockade treatment in RA.
引用
收藏
页码:760 / 769
页数:9
相关论文
共 50 条
  • [41] Benefit of anti-TNF therapy in rheumatoid arthritis patients with moderate disease activity
    Hyrich, Kimme L.
    Deighton, Chris
    Watson, Kath D.
    Symmons, Deborah P. M.
    Lunt, Mark
    RHEUMATOLOGY, 2009, 48 (10) : 1323 - 1327
  • [42] Infections in Patients With Rheumatoid Arthritis Undergoing Anti-TNF alpha Drug Therapy
    Alonso Ruiz, Alberto
    REUMATOLOGIA CLINICA, 2008, 4 : 18 - 23
  • [43] Effect of anti-TNF therapy and corticosteroids on the risk of stroke in patients with rheumatoid arthritis
    Michaud, K.
    Naclareishvili, Z.
    Wolfe, F.
    ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 : 182 - 183
  • [44] Anti-TNF therapy attrition rates and reasons for stopping in rheumatoid arthritis patients
    Pocock, J. M.
    Oestoer, A. J.
    RHEUMATOLOGY, 2008, 47 : II42 - II42
  • [45] RHEUMATOID ARTHRITIS Obesity impairs efficacy of anti-TNF therapy in patients with RA
    Gonzalez-Gay, Miguel A.
    Gonzalez-Juanatey, Carlos
    NATURE REVIEWS RHEUMATOLOGY, 2012, 8 (11) : 641 - 642
  • [46] Clinical parameters and biomarkers for anti-TNF treatment prognosis in rheumatoid arthritis patients
    Cuchacovich, Miguel
    Bueno, Daniel
    Carvajal, Rodrigo
    Bravo, Nicolas
    Carlos Aguillon, Juan
    Catalan, Diego
    Soto, Lilian
    CLINICAL RHEUMATOLOGY, 2014, 33 (12) : 1707 - 1714
  • [47] Clinical parameters and biomarkers for anti-TNF treatment prognosis in rheumatoid arthritis patients
    Miguel Cuchacovich
    Daniel Bueno
    Rodrigo Carvajal
    Nicolás Bravo
    Juan Carlos Aguillón
    Diego Catalán
    Lilian Soto
    Clinical Rheumatology, 2014, 33 : 1707 - 1714
  • [48] Clinical and experimental pain processing in rheumatoid arthritis patients treated with anti-TNF
    Wartolowska, K.
    Schweinhardt, P.
    Wordsworth, P.
    Chizh, B. A.
    Bountra, C.
    Chessell, I.
    Tracey, I.
    RHEUMATOLOGY, 2007, 46 : I6 - I7
  • [49] Effect of anti-TNF treatment on body composition and serum adiponectin levels of women with rheumatoid arthritis
    John Serelis
    Meropi D. Kontogianni
    Stergios Katsiougiannis
    Maria Bletsa
    Maria G. Tektonidou
    Fotini N. Skopouli
    Clinical Rheumatology, 2008, 27 : 795 - 797
  • [50] Effect of anti-TNF treatment on body composition and serum adiponectin levels of women with rheumatoid arthritis
    Serelis, John
    Kontogianni, Meropi D.
    Katsiougiannis, Stergios
    Bletsa, Maria
    Tektonidou, Maria G.
    Skopouli, Fotini N.
    CLINICAL RHEUMATOLOGY, 2008, 27 (06) : 795 - 797