Myelomeningocele in an infant with intrauterine exposure to efavirenz

被引：39
|
作者：
Saitoh A. [1 ]
Hull A.D. [2 ]
Franklin P. [1 ]
Spector S.A. [1 ]
机构：
[1] Division of Infectious Diseases, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093-0672
[2] Department of Reproductive Medicine, University of California San Diego, La Jolla, CA 92093-0672
来源：
Journal of Perinatology | 2005年 / 25卷 / 8期
关键词：
D O I：
10.1038/sj.jp.7211343
中图分类号：
学科分类号：
摘要：
We report a case of myelomeningocele in an infant whose mother was exposed to efavirenz during the first 16 weeks of pregnancy. Although the true risk for myelomeningocele with the use of efavirenz early in pregnancy is still unknown, the findings in humans are consistent with those observed in primates and suggest that efavirenz is a potent teratogen. Thus, we suggest that efavirenz only be prescribed for women of childbearing potential when no other comparable antiretroviral options are available. © 2005 Nature Publishing Group. All rights reserved.
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页码：555 / 556
页数：1
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