Effect of Heat Shock Protein 90 (Hsp90) on Migration and Invasion of Human Cancer Cells in Vitro

被引：0
|
作者：
A. V. Snigireva
V. V. Vrublevskaya
Yu. Yu. Skarga
Yu. V. Evdokimovskaya
O. S. Morenkov
机构：
[1] Institute of Cell Biophysics of Russian Academy of Sciences,
来源：
Bulletin of Experimental Biology and Medicine | 2014年 / 157卷
关键词：
heat shock protein 90 (Hsp90); cell migration; cell invasion;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We studied the effect of purifi ed native heat shock protein 90 (Hsp90) from bovine and mouse brain on migration and invasion of human glioblastoma (A-172) and fi brosarcoma (HT1080) cells. Hsp90 in concentrations of 0.01-0.10 mg/ml stimulated migration and invasion of tumor cells in vitro by 20-32% (p<0.05). Polyclonal antibodies to Hsp90 blocked the Hsp90-dependent stimulation of cell invasion, which indicates specifi city of the stimulating effect of extracellular Hsp90 on tumor cell invasion. Hence, extracellular Hsp90 can be considered as a promising molecular target, because its inhibition can suppress invasion and metastasizing of tumor cells.
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页码：476 / 478
页数：2
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