GSK-3β inhibition protects human nucleus pulposus cell against oxidative stress-inducing apoptosis through mitochondrial pathway

被引：0
|
作者：
Kai Zhu
Song Guo
Guoyi Han
Xiancheng Qiang
Mengmeng Ma
Qinglei Xu
Wenjie Tang
Jun Tan
机构：
[1] Tongji University School of Medicine,Department of Orthopaedics, Shanghai East Hospital
[2] Qingdao No.8 People’s Hospital,Department of Orthopaedics II
[3] Tongji University School of Medicine,Research Center for Translational Medicine, Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital
[4] Shanghai Jiaotong University,Department of Orthopaedics, Shanghai General Hospital
[5] Qingdao No.8 People’s Hospital,Department of Anesthesiology
来源：
Molecular Biology Reports | 2022年 / 49卷
关键词：
Intervertebral disc degeneration; GSK-3β; SB216763; Nucleus pulposus cells; Oxidative stress; Apoptosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：3783 / 3792
页数：9
相关论文
共 50 条
  • [21] Ghrelin protects against nucleus pulposus degeneration through inhibition of NF-κB signaling pathway and activation of Akt signaling pathway
    Li, Weiwei
    Wu, Xihai
    Qu, Ruize
    Wang, Wenhan
    Chen, Xiaomin
    Cheng, Lei
    Liu, Yaoge
    Guo, Linlin
    Zhao, Yunpeng
    Liu, Chao
    ONCOTARGET, 2017, 8 (54) : 91887 - 91901
  • [22] IL-8 PROTECTS PROSTATE CANCER CELLS FROM GSK-3β-INDUCED OXIDATIVE STRESS THROUGH ACTIVATING THE MTOR SIGNALING PATHWAY
    Sun, Yi
    Yang, Lu
    Wei, Qiang
    JOURNAL OF UROLOGY, 2019, 201 (04): : E1173 - E1174
  • [23] Activation of PI3K/PKB/GSK-3β signaling by sciadopitysin protects cardiomyocytes against high glucose-induced oxidative stress and apoptosis
    Zhang, Chujie
    Yu, Huimei
    Yang, Han
    Liu, Ben
    JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2021, 35 (10)
  • [24] Decreasing REDD1 expression protects against high glucose-induced apoptosis, oxidative stress and inflammatory injury in podocytes through regulation of the AKT/GSK-3β/Nrf2 pathway
    Wang, Xiaojing
    Yang, Jing
    Wang, Wenxing
    Li, Yun
    Yang, Yue
    IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2023, 45 (05) : 527 - 538
  • [25] Sodium butyrate protects against oxidative stress in high-fat-diet-induced obese rats by promoting GSK-3β/Nrf2 signaling pathway and mitochondrial function
    Tang, Xue
    Sun, Yongjuan
    Li, Yingrui
    Ma, Shuhua
    Zhang, Kai
    Chen, Ailing
    Lyu, Yipin
    Yu, Renqiang
    JOURNAL OF FOOD BIOCHEMISTRY, 2022, 46 (10)
  • [26] Shikonin protects against lipopolysaccharide-induced inflammation and apoptosis in human nucleus pulposus cells through the nuclear factor-kappa B pathway
    Liu, Yuanbin
    Zheng, Jiazhuang
    Chen, Yu
    Wang, Fandong
    Ye, He
    Wang, Miao
    Zhang, Zhi
    FOOD SCIENCE & NUTRITION, 2021, 9 (10): : 5583 - 5589
  • [27] Exploring allocryptopine as a neuroprotective agent against oxidative stress-induced neural apoptosis via Akt/GSK-3β/tau pathway modulation
    Aslim, Belma
    Dolanbay, Serap Nigdelioglu
    Baran, Sahra Setenay
    COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2024, 112
  • [28] Autophagy activation protects shock wave induced renal tubular epithelial cell apoptosis may through modulation of Akt/GSK-3β pathway
    Long, Qingzhi
    Li, Xiang
    He, Hui
    He, Dalin
    INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2016, 12 (12): : 1461 - 1471
  • [29] Sox9 protects against human lung fibroblast cell apoptosis induced by LPS through activation of the AKT/GSK3β pathway
    Zhankun Zhu
    Jinhua Dai
    Yufeng Liao
    Tao Wang
    Biochemistry (Moscow), 2017, 82 : 606 - 612
  • [30] Sox9 protects against human lung fibroblast cell apoptosis induced by LPS through activation of the AKT/GSK3β pathway
    Zhu, Zhankun
    Dai, Jinhua
    Liao, Yufeng
    Wang, Tao
    BIOCHEMISTRY-MOSCOW, 2017, 82 (05) : 606 - 612
12345