Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy

被引：0

作者：

Joshua Munger

Bryson D Bennett

Anuraag Parikh

Xiao-Jiang Feng

Jessica McArdle

Herschel A Rabitz

Thomas Shenk

Joshua D Rabinowitz

机构：

[1] Lewis Thomas Laboratory,Department of Molecular Biology

[2] Princeton University,Department of Biochemistry and Biophysics

[3] University of Rochester School of Medicine and Dentistry,Department of Chemistry and Lewis

[4] 601 Elmwood Ave,Sigler Institute for Integrative Genomics

[5] Box 712,Department of Chemistry

[6] Rochester,undefined

[7] New York 14642,undefined

[8] USA,undefined

[9] Carl Icahn Laboratory,undefined

[10] Princeton University,undefined

[11] Frick Laboratory,undefined

[12] Princeton University,undefined

来源：

Nature Biotechnology | 2008年 / 26卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Munger et al. show that infection with human cytomegalovirus upregulates fatty acid biosynthesis and that pharmacological inhibition of this pathway inhibits replication of both this virus and influenza A. This approach, the first to reliably map major carbon fluxes in mammalian cells, extends the promise of metabolomics from diagnostic applications to identification of new therapeutic concepts.

引用

页码：1179 / 1186

页数：7

共 22 条

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