Activin-A impedes the establishment of CD4+ T cell exhaustion and enhances anti-tumor immunity in the lung

被引：0
|
作者：
Ioannis Morianos
Aikaterini Tsitsopoulou
Konstantinos Potaris
Dimitrios Valakos
Ourania Fari
Giannis Vatsellas
Clementine Bostantzoglou
Andreas Photiades
Mina Gaga
Georgina Xanthou
Maria Semitekolou
机构：
[1] Cellular Immunology Laboratory,Department of Thoracic Surgery
[2] Biomedical Research Foundation of the Academy of Athens (BRFAA),Present address: Department of Medicine I, Comprehensive Cancer Center, Institute of Cancer Research
[3] Athens Chest Hospital ‘Sotiria’,Intensive Care Unit
[4] Molecular Biology Laboratory,7th Respiratory Medicine Department and Asthma Center
[5] BRFAA,undefined
[6] Medical University of Vienna,undefined
[7] Greek Genome Center,undefined
[8] BRFAA,undefined
[9] Athens Chest Hospital ‘Sotiria’,undefined
[10] Athens Chest Hospital ‘Sotiria’,undefined
来源：
Journal of Experimental & Clinical Cancer Research | / 40卷
关键词：
Activin-A; Anti-tumor immunity; CD4; T cells; Non-small cell lung cancer; T cell exhaustion; Immune regulation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [41] Both CD8+ T cells and CD4+ T cells are essential in mediating potent anti-tumor immunity of DNA vaccines expressing cytosolic antigens
    Ji, H
    Chen, H
    Kurman, RJ
    Pardoll, DM
    Wu, TC
    LABORATORY INVESTIGATION, 1999, 79 (01) : 118A - 118A
  • [42] The transcription factor IRF2 drives interferon-mediated CD8+T cell exhaustion to restrict anti-tumor immunity
    Lukhele, Sabelo
    Abd Rabbo, Diala
    Guo, Mengdi
    Shen, Jian
    Elsaesser, Heidi J.
    Quevedo, Rene
    Carew, Madeleine
    Gadalla, Ramy
    Snell, Laura M.
    Mahesh, Lawanya
    Ciudad, M. Teresa
    Snow, Bryan E.
    You-Ten, Annick
    Haight, Jillian
    Wakeham, Andrew
    Ohashi, Pamela S.
    Mak, Tak W.
    Cui, Weiguo
    McGaha, Tracy L.
    Brooks, David G.
    IMMUNITY, 2022, 55 (12) : 2369 - +
  • [43] CD4+ T-cell-mediated anti-tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis
    Zhang, Sheng
    Bernard, Dannie
    Khan, Waliul I.
    Kaplan, Mark H.
    Bramson, Jonathan L.
    Wan, Yonghong
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2009, 39 (05) : 1252 - 1259
  • [44] Depletion of regulatory T cells by anti-ICOS antibody enhances anti-tumor immunity of tumor cell vaccine in prostate cancer
    Mo, Lijun
    Chen, Qianmei
    Zhang, Xinji
    Shi, Xiaojun
    Wei, Lili
    Zheng, Dianpeng
    Li, Hongwei
    Gao, Jimin
    Li, Jinlong
    Hu, Zhiming
    VACCINE, 2017, 35 (43) : 5932 - 5938
  • [45] CD4+ T cell immunity to Salmonella is transient in the circulation
    Peres, Newton G.
    Wang, Nancy
    Whitney, Paul
    Engel, Sven
    Shreenivas, Meghanashree M.
    Comerford, Ian
    Hocking, Dianna M.
    Erazo, Anna B.
    Foerster, Irmgard
    Kupz, Andreas
    Gebhardt, Thomas
    McColl, Shaun R.
    McSorley, Stephen J.
    Bedoui, Sammy
    Strugnell, Richard A.
    PLOS PATHOGENS, 2021, 17 (10)
  • [46] Unbalanced neonatal CD4+ T-cell immunity
    Debock, Isabelle
    Flamand, Veronique
    FRONTIERS IN IMMUNOLOGY, 2014, 5
  • [47] Autophagy in CD4+ T-cell immunity and tolerance
    Luenemann, J. D.
    Muenz, C.
    CELL DEATH AND DIFFERENTIATION, 2009, 16 (01): : 79 - 86
  • [48] Autophagy in CD4+ T-cell immunity and tolerance
    J D Lünemann
    C Münz
    Cell Death & Differentiation, 2009, 16 : 79 - 86
  • [49] The role of CD4+ T cell responses in antitumor immunity
    Pardoll, DM
    Topalian, SL
    CURRENT OPINION IN IMMUNOLOGY, 1998, 10 (05) : 588 - 594
  • [50] ANTIVIRAL IMMUNITY Deconstructing CD4+ T cell memory
    Minton, Kirsty
    NATURE REVIEWS IMMUNOLOGY, 2012, 12 (09) : 619 - 619
12345