Yeast bcy1 mutants with stationary phase-specific defects

被引:0
|
作者
Vickie M. Peck
Edwina K. Fuge
Pamela A. Padilla
Maria A. Gomez
M. Werner-Washburne
机构
[1] Department of Biology,
[2] University of New Mexico,undefined
[3] Albuquerque,undefined
[4] NM 87131,undefined
[5] USA,undefined
来源
Current Genetics | 1997年 / 32卷
关键词
Key wordsbcy1; ubi4; ard1; Stationary phase;
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摘要
Entry into the stationary phase requires the yeast BCY1 gene, which encodes the regulatory subunit of the cAMP-dependent protein kinase (cAPK). New bcy1 mutants, constructed by in vitro mutagenesis of the 3′-region encoding the cAMP-binding domains, were classified as early or late-acting mutants based on viability studies. The late-acting bcy1 mutants accumulated fewer stationary phase-specific Bcy1p isoforms and had decreased cAPK activity. This late-acting class is novel and dies after 7 days in culture, later than two previously reported stationary phase mutants, ubi4 and ard1.
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页码:83 / 92
页数:9
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