Integrated genomic and molecular characterization of cervical cancer

被引：0

作者：

机构：

[1] Albert Einstein College of Medicine,

[2] Bronx,undefined

[3] Analytical Biological Services,undefined

[4] Inc.,undefined

[5] Barretos Cancer Hospital,undefined

[6] Baylor College of Medicine,undefined

[7] Beckman Research Institute of City of Hope,undefined

[8] Buck Institute for Research on Aging,undefined

[9] Canada’s Michael Smith Genome Sciences Centre,undefined

[10] BC Cancer Agency,undefined

[11] Harvard Medical School,undefined

[12] Helen F. Graham Cancer Center and Research Institute at Christiana Care Health Services,undefined

[13] Inc.,undefined

[14] HudsonAlpha Institute for Biotechnology,undefined

[15] The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University,undefined

[16] University of Alabama at Birmingham,undefined

[17] ILSbio,undefined

[18] LLC,undefined

[19] Indiana University School of Medicine,undefined

[20] Institute of Human Virology,undefined

[21] Institute for Systems Biology,undefined

[22] International Genomics Consortium,undefined

[23] Leidos Biomedical,undefined

[24] Massachusetts General Hospital,undefined

[25] McDonnell Genome Institute at Washington University,undefined

[26] Medical College of Wisconsin,undefined

[27] Medical University of South Carolina,undefined

[28] Memorial Sloan Kettering Cancer Center,undefined

[29] Montefiore Medical Center,undefined

[30] Bronx,undefined

[31] NantOmics,undefined

[32] National Cancer Institute,undefined

[33] National Hospital,undefined

[34] National Human Genome Research Institute,undefined

[35] National Institute of Environmental Health Sciences,undefined

[36] National Institute on Deafness and Other Communication Disorders,undefined

[37] Ontario Tumour Bank,undefined

[38] London Health Sciences Centre,undefined

[39] Ontario Tumour Bank,undefined

[40] Ontario Institute for Cancer Research,undefined

[41] Ontario Tumour Bank,undefined

[42] The Ottawa Hospital,undefined

[43] Oregon Health and Science University,undefined

[44] Penrose-St Francis Health Services,undefined

[45] Samuel Oschin Comprehensive Cancer Institute,undefined

[46] Cedars-Sinai Medical Center,undefined

[47] SRA International,undefined

[48] St Joseph’s Candler Health System,undefined

[49] The Research Institute at Nationwide Children’s Hospital,undefined

[50] The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University,undefined

来源：

Nature | 2017年 / 543卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Cervical cancer remains one of the leading causes of cancer-related deaths worldwide. Here we report the extensive molecular characterization of 228 primary cervical cancers, one of the largest comprehensive genomic studies of cervical cancer to date. We observed notable APOBEC mutagenesis patterns and identified SHKBP1, ERBB3, CASP8, HLA-A and TGFBR2 as novel significantly mutated genes in cervical cancer. We also discovered amplifications in immune targets CD274 (also known as PD-L1) and PDCD1LG2 (also known as PD-L2), and the BCAR4 long non-coding RNA, which has been associated with response to lapatinib. Integration of human papilloma virus (HPV) was observed in all HPV18-related samples and 76% of HPV16-related samples, and was associated with structural aberrations and increased target-gene expression. We identified a unique set of endometrial-like cervical cancers, comprised predominantly of HPV-negative tumours with relatively high frequencies of KRAS, ARID1A and PTEN mutations. Integrative clustering of 178 samples identified keratin-low squamous, keratin-high squamous and adenocarcinoma-rich subgroups. These molecular analyses reveal new potential therapeutic targets for cervical cancers.

引用

页码：378 / 384

页数：6

共 50 条

[41] The impact of integrated genomic analysis on molecular classifications and prognostic risk stratification in endometrial cancer
Zou, Dongling
Zheng, Qian
Feng, Manfeng
Shu, Jin
Min, Huang
Wang, Yanyan
Ma, Di
Huang, Hui
Wang, Dong
GYNECOLOGIC ONCOLOGY, 2024, 190 : S149 - S149
[42] Combination of High-throughput Genomic Technologies and Bioinformatics for Molecular Characterization of Cancer
Chuang, Eric Y.
PROCEEDINGS OF 2013 3RD INTERNATIONAL CONFERENCE ON INSTRUMENTATION, COMMUNICATIONS, INFORMATION TECHNOLOGY, AND BIOMEDICAL ENGINEERING (ICICI-BME), 2013, : 1 - 1
[43] Molecular and genomic characterization of a newly established male breast cancer cell line
Vaclova, Tereza
Maguire, Sarah
Pugh, Matthew
Barry, Peter
Orr, Nick
CANCER RESEARCH, 2017, 77
[44] Comparative genomic hybridization and molecular cytogenetic characterization of two prostate cancer xenografts
Williams, BJ
Jones, E
Kozlowski, JM
Vessella, R
Brothman, AR
GENES CHROMOSOMES & CANCER, 1997, 18 (04): : 299 - 304
[45] A Personalized Treatment for Lung Cancer: Molecular Pathways, Targeted Therapies, and Genomic Characterization
Hensing, Thomas
Chawla, Apoorva
Batra, Rishi
Salgia, Ravi
SYSTEMS ANALYSIS OF HUMAN MULTIGENE DISORDERS, 2014, 799 : 85 - 117
[46] Erratum: Integrated genomic characterization of endometrial carcinoma
Nature, 2013, 500 : 242 - 242
[47] Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma
Aguirre, Andrew J.
Hruban, Ralph H.
Raphael, Benjamin J.
CANCER CELL, 2017, 32 (02) : 185 - +
[48] Validation of a Patient-Derived Xenograft Model for Cervical Cancer Based on Genomic and Phenotypic Characterization
Miyamoto, Shunsuke
Tanaka, Tomohito
Hirosuna, Kensuke
Nishie, Ruri
Ueda, Shoko
Hashida, Sousuke
Terada, Shinichi
Konishi, Hiromi
Kogata, Yuhei
Taniguchi, Kohei
Komura, Kazumasa
Ohmichi, Masahide
CANCERS, 2022, 14 (12)
[49] Integrated Genomic Characterization of Papillary Thyroid Carcinoma
Agrawal, Nishant
Akbani, Rehan
Aksoy, B. Arman
Ally, Adrian
Arachchi, Harindra
Asa, Sylvia L.
Auman, J. Todd
Balasundaram, Miruna
Balu, Saianand
Baylin, Stephen B.
Behera, Madhusmita
Bernard, Brady
Beroukhim, Rameen
Bishop, Justin A.
Black, Aaron D.
Bodenheimer, Tom
Boice, Lori
Bootwalla, Moiz S.
Bowen, Jay
Bowlby, Reanne
Bristow, Christopher A.
Brookens, Robin
Brooks, Denise
Bryant, Robert
Buda, Elizabeth
Butterfield, Yaron S. N.
Carling, Tobias
Carlsen, Rebecca
Carter, Scott L.
Carty, Sally E.
Chan, Timothy A.
Chen, Amy Y.
Cherniack, Andrew D.
Cheung, Dorothy
Chin, Lynda
Cho, Juok
Chu, Andy
Chuah, Eric
Cibulskis, Kristian
Ciriello, Giovanni
Clarke, Amanda
Clayman, Gary L.
Cope, Leslie
Copland, John A.
Covington, Kyle
Danilova, Ludmila
Davidsen, Tanja
Demchok, John A.
DiCara, Daniel
Dhalla, Noreen
CELL, 2014, 159 (03) : 676 - 690
[50] Genomic and molecular characterization of preterm birth
Knijnenburg, Theo A.
Vockley, Joseph G.
Chambwe, Nyasha
Gibbs, David L.
Humphries, Crystal
Huddleston, Kathi C.
Klein, Elisabeth
Kothiyal, Prachi
Tasseff, Ryan
Dhankani, Varsha
Bodian, Dale L.
Wong, Wendy S. W.
Glusman, Gustavo
Mauldin, Denise E.
Miller, Michael
Slagel, Joseph
Elasady, Summer
Roach, Jared C.
Kramer, Roger
Leinonen, Kalle
Linthorst, Jasper
Baveja, Rajiv
Baker, Robin
Solomon, Benjamin D.
Eley, Greg
Iyer, Ramaswamy K.
Maxwell, George L.
Bernard, Brady
Shmulevich, Ilya
Hood, Leroy
Niederhuber, John E.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (12) : 5819 - 5827

← 1 2 3 4 5 →