Novel roles for hERG K+ channels in cell proliferation and apoptosis

被引：0
|
作者：
J Jehle
P A Schweizer
H A Katus
D Thomas
机构：
[1] Medical University Hospital,Department of Cardiology
来源：
Cell Death & Disease | 2011年 / 2卷
关键词：
hERG; K; channel; cell proliferation; apoptosis; anticancer therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The human ether-a-go-go-related gene potassium channel (hERG, Kv11.1, KCNH2) has an essential role in cardiac action potential repolarization. Electrical dysfunction of the voltage-sensitive ion channel is associated with potentially lethal ventricular arrhythmias in humans. hERG K+ channels are also expressed in a variety of cancer cells where they control cell proliferation and apoptosis. In this review, we discuss molecular mechanisms of hERG-associated cell cycle regulation and cell death. In addition, the significance of hERG K+ channels as future drug target in anticancer therapy is highlighted.
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页码：e193 / e193
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