Differentiation of embryonic stem cells into cardiomyocytes induced by leukemia inhibitory factor (LIF)

被引：0
|
作者：
Petrova R.R. [1 ]
Mezhevikina L.M. [1 ]
Fesenko E.E. [1 ]
机构：
[1] Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Oblast
来源：
Biophysics | 2006年 / 51卷 / 2期
基金：
俄罗斯基础研究基金会;
关键词：
Cardiomyocytes; Differentiation; Embryonic stem cells; Isoproterenol;
D O I：
10.1134/S0006350906020187
中图分类号：
学科分类号：
摘要：
An experimental model of mouse embryonic stem cell (ESC) differentiation into cells with contractile activity (similar to that of cardiomyocytes) without embryoid body formation has been obtained. The main factor inducing ESC differentiation along the cardiomyocyte pathway is recombinant cytokine LIF added in the course of long-term culturing. The contractile cells respond positively to treatment with isoproterenol, a cardioactive drug, which is evidence for the presence in these cells of β-adrenoreceptors characteristic of terminally differentiated mammalian cardiomyocytes. © 2006 Nauka/Interperiodica.
引用
收藏
页码：264 / 269
页数：5
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