Platinum(II) complexes of reduced amino acid ester Schiff bases: synthesis, characterization, and antitumor activity

被引：0
|
作者：
Li-Jun Li
Cheng Wang
Yu Qiao
Xiao-Yan Yang
Xing-Xing Hua
Jian-Long Du
机构：
[1] Hebei University,Chemical Biology Key Laboratory of Hebei Province
来源：
Research on Chemical Intermediates | 2014年 / 40卷
关键词：
Platinum(II) complexes; Reduced amino acid esters Schiff-bases; DNA interaction; Antitumor activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of platinum(II) complexes of reduced amino acid esters Schiff bases were synthesized as potential anticancer agents and characterized by 1H NMR, EA, IR, and molar conductivity. These compounds were tested for their DNA interaction with salmon sperm DNA by ultraviolet spectrum and CD spectrum, and their in vitro anticancer activities have been validated against HL-60, KB, BGC-823, and Bel-7402 cell lines by MTT assay. The cytotoxicity of complexes 5d and 5f are better than cisplatin against Bel-7402 cell lines, and show a close cytotoxic effect against HL-60 cell line.
引用
收藏
页码：413 / 424
页数：11
相关论文
共 50 条
  • [31] SYNTHESIS AND CHARACTERIZATION OF HIGHLY LIPOPHILIC ANTITUMOR PLATINUM(II) COMPLEXES
    KHOKHAR, AR
    XU, QY
    ALBAKER, S
    JOURNAL OF COORDINATION CHEMISTRY, 1991, 24 (01) : 77 - 82
  • [32] Cu(II) complexes with heterocyclic Schiff bases of 2-amino benzoxazole and acetophenone derivatives: Synthesis, characterization and biological activity
    Kumari, Suman
    Seema
    Yadav, Poonam
    Sharma, Shobhana
    Ranka, Mamta
    INDIAN JOURNAL OF CHEMISTRY, 2024, 63 (09): : 914 - 922
  • [33] Water-soluble monochloroplatinum(II) complexes with amino acid derived Schiff bases as ligands: synthesis, characterisation and antitumour activity
    Li, Li-Jun
    Tian, Chao
    Wang, Zheng
    Wang, Guang-Yuan
    Wang, Lian-Zeng
    Du, Jian-Long
    JOURNAL OF CHEMICAL RESEARCH, 2012, (02) : 85 - 89
  • [34] Synthesis and characterization of cobalt(II) and nickel(II) complexes of tridentate Schiff bases
    More, PG
    Bhalvankar, RB
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2006, 83 (02) : 113 - 115
  • [35] Synthesis and characterization of some novel amino acid Schiff base Fe(II) complexes
    Shaker, AM
    Awad, AM
    Nassr, LAE
    SYNTHESIS AND REACTIVITY IN INORGANIC AND METAL-ORGANIC CHEMISTRY, 2003, 33 (01): : 103 - 117
  • [36] SYNTHESIS AND CHARACTERIZATION OF AMINO-ACID SCHIFF-BASE COMPLEXES OF NICKEL(II)
    WANG, GB
    CHANG, JC
    SYNTHESIS AND REACTIVITY IN INORGANIC AND METAL-ORGANIC CHEMISTRY, 1994, 24 (07): : 1091 - 1097
  • [37] Synthesis, characterization and biological activity of some platinum(II) complexes with Schiff bases derived from salicylaldehyde, 2-furaldehyde and phenylenediamine
    Gaballa, Akmal S.
    Asker, Mohsen S.
    Barakat, Atiat S.
    Teleb, Said M.
    SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2007, 67 (01) : 114 - 121
  • [38] Synthesis, characterization and in vitro antitumor activity of nickel (II) and platinum (II) complexes with some thiophene thiosemicarbazones
    Al-Yafeai, Mariam
    Nimir, Hassan
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 255
  • [39] Synthesis and characterization of Cu(II), Cd(II) and Hg(II) complexes with Schiff bases
    Demir, Ibrahim
    Akkaya, Mustafa
    Bayrakci, Mevlut
    Pekacar, A. Ihsan
    ASIAN JOURNAL OF CHEMISTRY, 2007, 19 (05) : 3954 - 3958
  • [40] SYNTHESIS AND CHARACTERIZATION OF SOME NICKEL(II) SCHIFF-BASES COMPLEXES
    MASOUD, MS
    REFAAT, LS
    TRANSITION METAL CHEMISTRY, 1982, 7 (06) : 315 - 318
12345