p53 predominantly regulates IL-6 production and suppresses synovial inflammation in fibroblast-like synoviocytes and adjuvant-induced arthritis

被引:0
|
作者
Ting Zhang
Huihua Li
Juan Shi
Sha Li
Muyuan Li
Lei Zhang
Leting Zheng
Dexian Zheng
Fulin Tang
Xuan Zhang
Fengchun Zhang
Xin You
机构
[1] Peking Union Medical College Hospital,Department of Rheumatology and Clinical Immunology
[2] Chinese Academy of Medical Sciences & Peking Union Medical College,Basic Science Institute
[3] Key Laboratory of Rheumatology and Clinical Immunology,undefined
[4] Ministry of Education,undefined
[5] Chinese Academy of Medical Sciences & Peking Union Medical College,undefined
关键词
Rheumatoid arthritis; p53; Fibroblast-like synoviocytes; Interleukin-6; Signal transduction;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [41] Synovial Fluid IL-36γ in Patients with Enthesitis Related Arthritis (ERA) Correlates with Disease Activity and Leads to Production of IL-6 by Fibroblast Like Synoviocytes
    Aggarwal, Amita
    Majumder, Sanjukta
    Guleria, Shivika
    ARTHRITIS & RHEUMATOLOGY, 2021, 73 : 2102 - 2104
  • [42] Therapeutic effects of shikonin on adjuvant-induced arthritis in rats and cellular inflammation, migration and invasion of rheumatoid fibroblast-like synoviocytes via blocking the activation of Wnt/βcatenin pathway
    Liu, Fang-yuan
    Wang, Meng-qing
    Liu, Ming-ming
    Li, Tao
    Wang, Xiao-hua
    Jiang, Fei
    Wu, Xin-jie
    Cheng, Juan
    Cai, Li
    Li, Rong
    PHYTOMEDICINE, 2023, 116
  • [43] Nicotine inhibits tumor necrosis factor-α induced IL-6 and IL-8 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis
    Yaou Zhou
    Xiaoxia Zuo
    Yisha Li
    Yanping Wang
    Hongjun Zhao
    Xianzhong Xiao
    Rheumatology International, 2012, 32 : 97 - 104
  • [44] Nicotine inhibits tumor necrosis factor-α induced IL-6 and IL-8 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis
    Zhou, Yaou
    Zuo, Xiaoxia
    Li, Yisha
    Wang, Yanping
    Zhao, Hongjun
    Xiao, Xianzhong
    RHEUMATOLOGY INTERNATIONAL, 2012, 32 (01) : 97 - 104
  • [45] Silencing aquaporin 1 inhibits autophagy to exert anti-rheumatoid arthritis effects in TNF-α-induced fibroblast-like synoviocytes and adjuvant-induced arthritis rats
    Zhang, Man-yu
    Wang, Meng-qing
    Huang, Yan
    Gu, Sheng-long
    Zhou, Meng-yuan
    Xu, Ze-shan
    Li, Ling-ling
    Lv, Min
    Cai, Li
    Li, Rong
    INFLAMMATION RESEARCH, 2025, 74 (01)
  • [46] Inhibition of transient receptor potential canonical 6 attenuates fibroblast-like synoviocytes mediated synovial inflammation and joint destruction in rheumatoid arthritis
    Liu, G.
    Xu, D.
    He, Y.
    Xu, J.
    Huang, S.
    Zhang, W.
    Qiu, X.
    Wang, X.
    Li, J.
    Huang, J.
    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2021, 39 (01) : 115 - 124
  • [47] IL-34 Upregulated Th17 Production through Increased IL-6 Expression by Rheumatoid Fibroblast-Like Synoviocytes
    Wang, Bing
    Ma, Zijian
    Wang, Miaomiao
    Sun, Xiaotong
    Tang, Yawei
    Li, Ming
    Zhang, Yan
    Li, Fang
    Li, Xia
    MEDIATORS OF INFLAMMATION, 2017, 2017
  • [48] Ginkgolide B attenuates collagen-induced rheumatoid arthritis and regulates fibroblast-like synoviocytes-mediated apoptosis and inflammation
    Xie, Chuanmei
    Jiang, Jing
    Liu, Jianping
    Yuan, Guohua
    Zhao, Zhenyi
    ANNALS OF TRANSLATIONAL MEDICINE, 2020, 8 (22)
  • [49] Mangiferin exert protective effects on joints of adjuvant-induced arthritis rats by regulating the MAPKs/NF-κB pathway of fibroblast-like synoviocytes
    Wang, Ran
    Liu, Jing
    Wang, Zhehuan
    Wu, Xiaohan
    Guo, Hui
    Jiao, Xiangyue
    Zhang, Huiru
    Qi, Caihong
    Li, Xiaotian
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 101
  • [50] Rheumatoid Arthritis Synovial IL-21+CD4+T Cells Specifically Induce Matrix Metalloproteinase Production By Fibroblast-Like Synoviocytes
    Lebre, Maria C.
    Vieira, Pedro L.
    Aarrass, Saida
    Newsom-Davis, Thomas
    Tak, Paul Peter
    Screaton, Gavin R.
    ARTHRITIS AND RHEUMATISM, 2013, 65 : S700 - S700