Expression of bcl-2 protein in lymphocytes of patients with laryngeal carcinoma

被引:0
|
作者
J. Klatka
J. Roliński
K. Kupisz
S. Klonowski
D. Skomra
机构
[1] Otolaryngology Department,
[2] Medical Academy,undefined
[3] Lublin,undefined
[4] Poland,undefined
[5] Department of Clinical Immunology,undefined
[6] Medical Academy,undefined
[7] Lublin,undefined
[8] Poland,undefined
[9] Chair and Department of Pathomorphology,undefined
[10] Lublin,undefined
[11] Poland,undefined
来源
European Archives of Oto-Rhino-Laryngology | 1999年 / 256卷
关键词
Key words Laryngeal carcinoma; BCL-2 oncoprotein; T lymphocytes;
D O I
暂无
中图分类号
学科分类号
摘要
The aim of this study was to evaluate the expression of bcl-2 protein in lymphocytes of the peripheral blood of patients with laryngeal carcinoma. The protein product of the proto-oncogene bcl-2 is a physiological inhibitor of apoptosis or programmed cell death. Since we believe that apoptosis is involved in the regulation of an immune response to a cancer process, we tried to show how this mechanism works in laryngeal carcinoma in comparison with normal peripheral blood lymphocytes of healthy controls. To explain the significance of this molecule’s expression, we used flow cytometry to examine the expression of bcl-2 in T lymphocytes from the peripheral blood of 23 patients with laryngeal carcinoma and 20 healthy controls. Our study revealed that the expression of bcl-2 protein in T lymphocytes from the cancer patients was significantly higher than in the controls (P < 0.05). This difference in the expression of bcl-2 protein was found in both CD4 and CD8 subpopulations and was significantly higher than in the control group. In patients with laryngeal carcinoma expression of bcl-2 protein in T lymphocytes was higher in CD4 than in CD8 cells (P < 0.05). These results suggest that bcl-2 protein may interact in the regulation of apoptosis of lymphocytes, taking part in anti-cancer defence.
引用
收藏
页码:299 / 302
页数:3
相关论文
共 50 条
  • [41] The expression of Bcl-2 family proteins (Bcl-2, Bcl-x, Bax, Bak and Bim) in human lymphocytes
    Yokoyama, T
    Tanahashi, M
    Kobayashi, Y
    Yamakawa, Y
    Maeda, M
    Inaba, T
    Kiriyama, M
    Fukai, I
    Fujii, Y
    IMMUNOLOGY LETTERS, 2002, 81 (02) : 107 - 113
  • [42] Bcl-2 protein expression in acute and chronic hepatitis, cirrhosis and hepatocellular carcinoma
    Nakopoulou, L
    Stefanaki, K
    Vourlakou, C
    Manolaki, N
    Gakiopoulou, H
    Michalopoulos, G
    PATHOLOGY RESEARCH AND PRACTICE, 1999, 195 (01) : 19 - 24
  • [43] Laminin, bcl-2 protein and Ki-67 expression in vulvar carcinoma
    Drew, PA
    Malik, SN
    Wilkinson, EJ
    MODERN PATHOLOGY, 1998, 11 (01) : 103A - 103A
  • [44] BCL-2 family protein expression and platinum drug resistance in ovarian carcinoma
    Beale, PJ
    Rogers, P
    Boxall, F
    Sharp, SY
    Kelland, LR
    BRITISH JOURNAL OF CANCER, 2000, 82 (02) : 436 - 440
  • [45] BCL-2 PROTEIN EXPRESSION IN THE BARRETTS METAPLASIA DYSPLASIA-CARCINOMA SEQUENCE
    GOLDBLUM, JR
    RICE, TW
    MODERN PATHOLOGY, 1995, 8 (08) : 866 - 869
  • [46] Significance of c-Myc and Bcl-2 protein expression in nasopharyngeal carcinoma
    Yu, YQ
    Dong, WD
    Li, X
    Yu, EJ
    Zhou, XR
    Li, SH
    ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 2003, 129 (12) : 1322 - 1326
  • [47] BCL-2 family protein expression and platinum drug resistance in ovarian carcinoma
    Beale P.J.
    Rogers P.
    Boxall F.
    Sharp S.Y.
    Kelland L.R.
    British Journal of Cancer, 2000, 82 (2) : 436 - 440
  • [48] Effects of diphencyprone on expression of Bcl-2 protein in patients with Alopecia areata
    Pazoki-Toroudi, Hamidreza
    Ajami, Marjan
    Babakoohi, Shahab
    Khaki, Leila
    Habibey, Rouhollah
    Akhiani, Maryam
    Seirafi, Hassan
    Firooz, Alireza
    IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2010, 32 (03) : 422 - 425
  • [49] Fas and Bcl-2 protein expression in thyrocytes of patients with nodular goiter
    Andrikoula, M
    Vartholomatos, G
    Tsangaris, GT
    Bafa, M
    Tzortzatou-Stathopoulou, F
    Tsatsoulis, A
    EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2001, 145 (04) : 403 - 407
  • [50] Expression of Bcl-2 Protein in Palatine Tonsil of IgA Nephropathy Patients
    Sunaga, Hiroshi
    Fujieda, Shigeharu
    RECENT ADVANCES IN TONSILS AND MUCOSAL BARRIERS OF THE UPPER AIRWAYS, 2011, 72 : 192 - 192