Association of the colorectal cancer and MDR1 gene polymorphism in an Iranian population

被引:0
|
作者
Azam Khedri
Amireh Nejat-Shokouhi
Roham Salek
Habibollah Esmaeili
Ali Mokhtarifar
Reza Entezari Heravi
Farnoosh Tatari
Javad Behravan
Behnoosh Miladpour
Shahireh Omidvar Tehrani
机构
[1] Islamic Azad University Branch Masjedsoleiman,Department of Clinical Biochemistry
[2] Mashhad University of Medical Sciences,Omid and Imam Reza Hospital, Cancer Research Center
[3] Mashhad University of Medical Sciences,Department of Medical Statistics
[4] Mashhad University of Medical Sciences,Department of Internal Medicine
[5] Imam Reza Hospital,Biotechnology Research Center, School of Pharmacy
[6] Mashhad University of Medical Sciences,Department of Pharmaceutical Biotechnology
[7] Mashhad University of Medical Sciences,Biotechnology Research Center
[8] School of Pharmacy,undefined
[9] Mashhad University of Medical Sciences,undefined
来源
Molecular Biology Reports | 2011年 / 38卷
关键词
Colorectal cancer; P-gp; C3435T polymorphism;
D O I
暂无
中图分类号
学科分类号
摘要
The human multidrug resistance (MDR1) gene product P-glycoprotein is highly expressed in intestinal epithelial cells, where it constitutes a barrier against xenobiotics, bacterial toxins, drugs and other biologically active compounds, possibly carcinogens. In this study, an association of MDR1 gene polymorphism and the occurrence of colorectal cancer were evaluated. In this case-control-designed 118 unrelated colorectal cancer and 137 sex-and-ages matched healthy controls were enrolled. The C3435T MDR1 gene polymorphism was identified using the polymerase chain reaction-restriction fragment length polymorphism method. Significantly increased frequencies of the 3435T allele and the 3435TT were observed in patients with colorectal cancer compared with controls (P = 0.03; OR, 95% CI; 1.46 for 3435T allele and P = 0.003; OR, 95% CI; 2.2 for 3435TT genotype). In contrast, frequency of genotype TT was significantly higher in controls compared to colorectal cancer (P = 0.006; OR, 95% CI; 0.49 for TC genotype). In this study suggest that C3435T MDR1 polymorphism has an association with colorectal cancer. The results support that the presence of allele C results in decreased susceptibility to colorectal cancer.
引用
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页码:2939 / 2943
页数:4
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