Antimicrobial resistance in E. Coli associated with urinary tract infection in the West of Ireland

被引:0
|
作者
Ni Chulain M. [1 ]
Murray A.-M. [1 ]
Corbett-Feeney G. [1 ]
Cormican M. [1 ,2 ]
机构
[1] Dept. of Bacteriology, National University of Ireland, Galway
[2] Dept. of Medical Microbiology, University College Hospital Galway, Galway
关键词
Urinary Tract Infection; Trimethoprim; Antimicrobial Resistance; Nalidixic Acid; Empiric Therapy;
D O I
10.1007/BF03168974
中图分类号
学科分类号
摘要
Background: Knowledge of antimicrobial resistance patterns in E. coli, the predominant pathogen associated with urinary tract infection (UTI) is important as a guide in selecting empirical antimicrobial therapy. Aims: To describe the antimicrobial susceptibility of E. coli associated with UTI in a region in the West of Ireland. Methods: A collection of 934 E. coli isolates associated with UTI were tested for susceptibility to a panel of antimicrobial agents by the disc diffusion method of the National Committee for Clinical Laboratory Standards. Results: More than 50% of E. coli were resistant to ampicillin, more than 40% resistant to sulphonamide and more than 30% resistant to trimethoprim. From 7.9% (community) to 12.5% (hospital) are resistant to co-amoxiclav with approximately 20% of isolates of intermediate susceptibility. In general practice most E. coli remain susceptible to nitrofurantoin (96.7%), nalidixic acid (93.9%) and ciprofloxacin (94.7%). For all agents rates of resistance were higher in hospital as compared with general practice isolates. Three isolates with the phenotype of Extended Spectrum Beta-lactamase (ESBL) resistance were detected. Conclusions: Ampicillin/amoxicillin are not suitable for empiric therapy of UTI in general practice or hospital patients in this region. There is doubt as to the role of trimethorpim or co-trimoxazole for empiric therapy of UTI. Nitrofurantoin, nalidixic acid and ciprofloxacin are active against the great majority of UTI associated E. coli.
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页码:6 / 9
页数:3
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