Thermosensitive Cotton Textile Loaded with Cyclodextrin-complexed Curcumin as a Wound Dressing

The moisture conditions and temperature changes are two key factors affecting wound management. Thermosensitive hydrogels are ideal dressing materials since they can maintain a moist environment at the wound site and release additional bioactive molecules to treat the wound when the area is infected. In this study, we developed a novel thermosensitive dressing based on cotton fabric as a matrix to provide robust mechanical properties. Inclusion complexes between cyclodextrins (HP-β-CD, DM-β-CD, and β-CDP) and curcumin were prepared and loaded into the thermosensitive dressing to obtain drug-release properties. The cotton coated with a thermosensitive polymer (CS-g-PVCL) that was crosslinked by citric acid to form a hydrogel was loaded with the appropriate inclusion complex chosen based on phase solubility studies. This composite dressing was investigated to characterize its wound management properties, such as the water vapor permeability and drug release behavior in response to the temperature. The resulting cytotoxicity, antibacterial, and antioxidant properties suggest the potential use of this thermosensitive-hydrogel-functionalized textile as an active wound dressing.