Shifting Paradigm in the Management of Anal Canal Carcinoma

被引：4
|
作者：
Mallick S. [1 ]
Benson R. [1 ]
Julka P.K. [1 ]
Rath G.K. [1 ]
机构：
[1] Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi
来源：
Journal of Gastrointestinal Cancer | 2015年 / 46卷 / 1期
关键词：
Anal canal; Chemoradiotherapy; Concurrent;
D O I：
10.1007/s12029-014-9673-0
中图分类号：
学科分类号：
摘要：
Background: Anal canal is the lower most part of the gastrointestinal tract harbouring 4 % of all gastrointestinal cancer. Most common treatment for anal canal carcinoma includes chemoradiotherapy. Methodology: We reviewed the recent landmark trials to find a road map in the management of anal canal carcinoma. Results: Concurrent chemoradiotherapy appears to be the most effective treatment schedule. Induction, as well as maintenance chemotherapy, has no definite role. Moderate dose radiation 50.4–54 Gy with concurrent mitomycin C (MMC) and 5-fluorouracil (5-FU) remains the standard. Split course is detrimental. Intensity-modulated radiotherapy and targeted drugs are investigated. Conclusion: Combined modality therapy is the standard for anal canal carcinoma. © 2014, Springer Science+Business Media New York.
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页码：1 / 4
页数：3
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