Complement receptor type two (CR2,CR21)A target for influencing the humoral immune response and antigen-trapping

被引：0
|
作者：
Wolfgang M. Prodinger
机构：
[1] University of Innsbruck,Institut für Hygiene
来源：
Immunologic Research | 1999年 / 20卷
关键词：
Complement; C3; Receptor; CD21; Structure; Immunity; EBV; Therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cellular receptors for complement C3 fragments deposited on antigens are important bricks in the wall defending against microbial pathogens. The part of complement receptor type 2 (CR2; CD21) deals with enhancing humoral immune responses and with long-term trapping of C3d-coated antigen by follicular dendritic cells. CR2 is also pivotal for Epstein-Barr virus (EBV) infection. Here, the current understanding, how CR2 interacts with its ligands C3d, EBV, and CD23 is summarized. The potential to target CR2 for clinical therapy or immunization purposes are discussed.
引用
收藏
页码：187 / 194
页数：7
相关论文
共 50 条
  • [41] B cell expression of the complement receptor 2 (CR2/CD21) constitutes a novel biomarker for COVID-19 severity
    Marcos-Jimenez, Ana
    Delgado-Wick, Pablo
    Diaz-Fernandez, Paula
    Montes, Nuria
    Fernandez-Lazaro, Iris
    Andreu-Martinez, Rosa M.
    Lopez, Noelia
    Cuesta-Mateos, Carlos
    Munoz-Calleja, Cecilia
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2024, 54 : 1680 - 1680
  • [42] An intronic silencer regulates B lymphocyte cell- and stage-specific expression of the human complement receptor type 2 (CR2, CD21) gene
    Makar, KW
    Pham, CTN
    Dehoff, MH
    O'Connor, SM
    Jacobi, SM
    Holers, VM
    JOURNAL OF IMMUNOLOGY, 1998, 160 (03): : 1268 - 1278
  • [43] Peripheral B cells hypo-responsive to antigenic challenge develop in transgenic mice that prematurely express complement receptor type 2 (CR2/CD21)
    Kulik, L
    Marchbank, KJ
    Haluszczak, C
    Morgan, P
    Holers, MV
    FASEB JOURNAL, 2003, 17 (07): : C95 - C95
  • [44] Characterization of C3dg binding to a recess formed between short consensus repeats 1 and 2 of complement receptor type 2 (CR2; CD21)
    Prodinger, WM
    Schwendinger, MG
    Schoch, J
    Köchle, M
    Larcher, C
    Dierich, MP
    JOURNAL OF IMMUNOLOGY, 1998, 161 (09): : 4604 - 4610
  • [45] ANALYSIS OF EPITOPE EXPRESSION AND THE FUNCTIONAL REPERTOIRE OF RECOMBINANT COMPLEMENT RECEPTOR-2 (CR2/CD21) IN MOUSE AND HUMAN-CELLS
    CAREL, JC
    FRAZIER, B
    LEY, TJ
    HOLERS, VM
    JOURNAL OF IMMUNOLOGY, 1989, 143 (03): : 923 - 930
  • [46] Transcriptional effects of a lupus-associated polymorphism in the 5′ untranslated region (UTR) of human complement receptor 2 (CR2/CD21)
    Cruickshank, Mark N.
    Karimi, Mahdad
    Mason, Rhonda L.
    Fenwick, Emily
    Mercer, Tim
    Tsao, Betty P.
    Boackle, Susan A.
    Ulgiati, Daniela
    MOLECULAR IMMUNOLOGY, 2012, 52 (3-4) : 165 - 173
  • [47] Revisiting the Coreceptor Function of Complement Receptor Type 2 (CR2, CD21); Coengagement With the B-Cell Receptor Inhibits the Activation, Proliferation, and Antibody Production of Human B Cells
    Kovacs, Kristof G.
    Macsik-Valent, Bernadett
    Matko, Janos
    Bajtay, Zsuzsa
    Erdei, Anna
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [48] The affinity threshold for human B cell activation via the antigen receptor complex is reduced upon co-ligation of the antigen receptor with CD21 (CR2)
    Mongini, PKA
    Vilensky, MA
    Highet, PF
    Inman, JK
    JOURNAL OF IMMUNOLOGY, 1997, 159 (08): : 3782 - 3791
  • [49] Biophysical Investigations of Complement Receptor 2 (CD21 and CR2)-Ligand Interactions Reveal Amino Acid Contacts Unique to Each Receptor-Ligand Pair
    Kovacs, James M.
    Hannan, Jonathan P.
    Eisenmesser, Elan Z.
    Holers, V. Michael
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (35) : 27251 - 27258
  • [50] Complement receptor CR2/CR1 deficiency protects mice from collagen-induced arthritis and associates with reduced autoantibodies to type II collagen and citrullinated antigens
    Kuhn, Kristine A.
    Cozine, Cassy L.
    Tomooka, Beren
    Robinson, William H.
    Holers, V. Michael
    MOLECULAR IMMUNOLOGY, 2008, 45 (10) : 2808 - 2819
12345