Optimizing fluorine labelling for 19F solid-state NMR in oriented biological systems

被引：0
|
作者：
Ian M. Robertson
Brittney A. Klein
Brian D. Sykes
机构：
[1] Ministry of Health,Department of Biochemistry
[2] Government of Alberta,undefined
[3] University of Alberta,undefined
来源：
Journal of Biomolecular NMR | 2020年 / 74卷
关键词：
19F NMR; Fluorine labelling; Solid-state NMR; Chemical shift anisotropy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
When planning a fluorine labeling strategy for 19F solid state NMR (ssNMR) studies of the structure and/or mobility of fluorine labeled compounds in situ in an oriented biological system, it is important to characterize the NMR properties of the label. This manuscript focuses on the characterization of a selection of aromatic fluorine compounds in dimyristoylphosphatidylcholine bilayers using 19F ssNMR from the standpoint of determining the optimum arrangement of fluorine nuclei on a pendant aromatic ring before incorporation into more complex biological systems.
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页码：1 / 7
页数：6
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