Targeting the epigenome for treatment of cancer

被引：0
|
作者：
E-J Geutjes
P K Bajpe
R Bernards
机构：
[1] Centre for Biomedical Genetics and Cancer Genomics Centre,Division of Molecular Carcinogenesis
[2] The Netherlands Cancer Institute,undefined
来源：
Oncogene | 2012年 / 31卷
关键词：
cancer epigenetics; epigenetic therapy; DNA methylation; histone modifications; nucleosome remodelling;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cancer genome analyses have revealed that the enzymes involved in epigenetic gene regulation are frequently deregulated in cancer. Here we describe the enzymes that control the epigenetic state of the cell, how they are affected in cancer and how this knowledge can be exploited to treat cancer with a new arsenal of selective therapies.
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收藏
页码：3827 / 3844
页数：17
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