Control of intracellular calcium bursting oscillations using method of self-organization

The contribution of this paper is to show a method for controlling intracellular calcium bursting oscillations including frequency and magnitude that have not been controllable before. The method is based on an understanding of system level behaviors as a phenomenon of self-organization. In these systems, the overall function is a consequence of the interaction between the system’s elements. Therefore, if the aim is to control the system’s signals and overall function, it seems reasonable to interact with its elements. In this paper the method is investigated by means of the calcium-induced calcium release (CICR) model proposed by Borghans et al. and a number of representative simulations of intracellular calcium bursting oscillations are used to illustrate the control of these oscillations.