Solid phase synthesis of functionalized biaryl ethers: Versatile scaffolds for combinatorial chemistry

被引：0
|
作者：
Jac C.H.M. Wijkmans
Andrew J. Culshaw
Anthony D. Baxter
机构：
[1] Oxford Diversity,
[2] A Division of Oxford Asymmetry Ltd.,undefined
来源：
Molecular Diversity | 1997年 / 3卷
关键词：
aromatic nucleophilic substitution; biaryl ethers; biaryl thioethers; scaffolds;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
4-Fluoro-3-nitrobenzoic acid attached to a solid support was shown to react under mild conditions with a wide range of functionalized phenols to yield, after cleavage, the corresponding biaryl ethers in excellent purity. In a similar fashion, biaryl thioethers could be obtained. Further elaboration of immobilized biaryl ethers demonstrates the potential for combinatorial library generation.
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页码：117 / 120
页数：3
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