Comparison of antimicrobial efficacy of a fixed dose combination of ceftazidime + sulbactam with ceftazidime and sulbactam alone against five bacteria

被引：0
|
作者：
S. M. Shrivastava
S. K. Shukla
M. Chaudhary
机构：
[1] Phase I (Extn) Bhatoli Kalan,Venus Medicine Research Center, Hill Top, Industrial Estate, Jharmajri EPIP
来源：
Folia Microbiologica | 2009年 / 54卷
关键词：
Minimum Inhibitory Concentration; Ceftazidime; Cefoperazone; Sulbactam; Mycobacterium Smegmatis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The efficacy of the agents was evaluated on the basis of minimum inhibitory concentration (MIC) and time-kill curve analysis in Pseudomonas aeruginosa, Staphylococcus aureus, Acinetobacter baumannii, Mycobacterium smegmatis, and Citrobacter braakii; MIC was found to be 0.5, 4.0, 0.015625, 0.0078125, and 0.0625 mg/L in FDC of ceftazidime + sulbactam, respectively, which is lower than ceftazidime and sulbactam individually. Time-kill curve analysis demonstrated maximum killing of bacteria after 4 h. A fixed dose combination of ceftazidime + sulbactam was found to have stronger antibacterial properties than ceftazidime and sulbactam alone at in vitro analysis.
引用
收藏
页码：391 / 394
页数：3
相关论文
共 50 条
  • [31] INVIVO EFFICACY OF CEFOPERAZONE ALONE AND IN COMBINATION WITH SULBACTAM OR AND AMIKACIN AGAINST METHICILLIN SENSITIVE AND RESISTANT STAPHYLOCOCCI, ENTEROCOCCI, PNEUMOCOCCI, AND PSEUDOMONADS IN A NEUTROPENIC SITE MODEL
    FASCHING, C
    MOODY, J
    LISSACK, L
    TENQUIST, J
    PETERSON, L
    CLINICAL RESEARCH, 1988, 36 (06): : A882 - A882
  • [32] In Vitro Activity of Minocycline Alone and in Combination with Cefoperazone-Sulbactam Against Carbapenem-Resistant Acinetobacter baumannii
    Pei, Guangsheng
    Mao, Yimin
    Sun, Yuxia
    MICROBIAL DRUG RESISTANCE, 2012, 18 (06) : 574 - 577
  • [33] INVITRO ACTIVITY AGAINST CLINICALLY IMPORTANT GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA OF SULBACTAM, ALONE AND IN COMBINATION WITH AMPICILLIN, CEFOTAXIME, MEZLOCILLIN, AND PIPERACILLIN
    SCHMALRECK, AF
    WILDFEUER, A
    ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1990, 40-2 (10): : 1145 - 1155
  • [34] In vitro pharmacokinetics/pharmacodynamics of continuous ceftazidime infusion alone and in combination with colistin against Pseudomonas aeruginosa biofilm
    Gomez-Junyent, Joan
    Murillo, Oscar
    Yu, Heidi H.
    Azad, Mohammad A. K.
    Wickremasinghe, Hasini
    Rigo-Bonnin, Raul
    Benavent, Eva
    Ariza, Javier
    Li, Jian
    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2021, 57 (02)
  • [35] Efficacy of ceftazidime/avibactam in monotherapy or combination therapy against carbapenem-resistant Gram-negative bacteria: A meta-analysis
    Onorato, Lorenzo
    Di Caprio, Giovanni
    Signoriello, Simona
    Coppola, Nicola
    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2019, 54 (06) : 735 - 740
  • [36] EFFICACY OF CEFTAZIDIME AND AZTREONAM ALONE OR IN COMBINATION WITH AMIKACIN IN EXPERIMENTAL LEFT-SIDED PSEUDOMONAS-AERUGINOSA ENDOCARDITIS
    PEFANIS, A
    GIAMARELLOU, H
    KARAYIANNAKOS, P
    DONTA, I
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (02) : 308 - 313
  • [37] In vitro antimicrobial efficacy of a fixed-dose combination of RHZE against M-tuberculosis
    Agertt, Vanessa Albertina
    Bonez, Pauline Cordenonsi
    Mizdal, Caren Rigon
    Rossi, Grazielle Guidolin
    Flores, Vanessa da Costa
    Anraku de Campos, Marli Matiko
    BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 52 (03) : 575 - 580
  • [38] In Vitro Activity of Ceftazidime/Avibactam Alone and in Combination With Fosfomycin and Carbapenems Against KPC-producing Klebsiella Pneumoniae
    Romanelli, Federica
    De Robertis, Annalisa
    Carone, Gianluca
    Dalfino, Lidia
    Stufano, Monica
    Del Prete, Raffaele
    Mosca, Adriana
    NEW MICROBIOLOGICA, 2020, 43 (03): : 136 - 138
  • [39] Ceftazidime/avibactam alone or in combination with aztreonam against colistin-resistant and carbapenemase-producing Klebsiella pneumoniae
    Jayol, Aurelie
    Nordmann, Patrice
    Poirel, Laurent
    Dubois, Veronique
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2018, 73 (02) : 542 - 544
  • [40] Characterization of In Vitro Antimicrobial Activity of Vertilmicin Alone and in Combination with Ceftazidime by Using Semi-mechanistic Pharmacokinetic/Pharmacodynamic Model
    Zhuang, Luning
    Sy, Sherwin K. B.
    Xia, Huiming
    Singh, Rajendra P.
    Liu, Changxiao
    Derendorf, Hartmut
    JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2013, 40 : S26 - S26
12345