Hypermutation by intersegmental transfer of APOBEC3G cytidine deaminase

被引：0
|
作者：
Roni Nowarski
Elena Britan-Rosich
Tamar Shiloach
Moshe Kotler
机构：
[1] the Hebrew University-Hadassah Medical School,Department of Pathology and the Lautenberg Center for General and Tumor Immunology
来源：
Nature Structural & Molecular Biology | 2008年 / 15卷
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摘要：
APOBEC3G is a cytidine deaminase that can be incorporated into HIV-1 virions and process the viral genome upon cell infection, leading to viral hypermutation and inactivation. APOBEC3G's activities are counteracted by viral protein Vif. Using a sensitive enzymatic assay, low levels of APOBEC3G can be detected associated to Vif(+) virions. Furthermore, the authors show that APOBEC3G functions in a distributive manner and causes dispersed hypermutation via intersegmental transfer.
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页码：1059 / 1066
页数：7
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