Hypermutation by intersegmental transfer of APOBEC3G cytidine deaminase

被引：0
|
作者：
Roni Nowarski
Elena Britan-Rosich
Tamar Shiloach
Moshe Kotler
机构：
[1] the Hebrew University-Hadassah Medical School,Department of Pathology and the Lautenberg Center for General and Tumor Immunology
来源：
Nature Structural & Molecular Biology | 2008年 / 15卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
APOBEC3G is a cytidine deaminase that can be incorporated into HIV-1 virions and process the viral genome upon cell infection, leading to viral hypermutation and inactivation. APOBEC3G's activities are counteracted by viral protein Vif. Using a sensitive enzymatic assay, low levels of APOBEC3G can be detected associated to Vif(+) virions. Furthermore, the authors show that APOBEC3G functions in a distributive manner and causes dispersed hypermutation via intersegmental transfer.
引用
收藏
页码：1059 / 1066
页数：7
相关论文
共 50 条
  • [1] Hypermutation by intersegmental transfer of APOBEC3G cytidine deaminase
    Nowarski, Roni
    Britan-Rosich, Elena
    Shiloach, Tamar
    Kotler, Moshe
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2008, 15 (10) : 1059 - 1066
  • [2] RNA Exclusion Mechanism of the Cytidine Deaminase APOBEC3G
    Solomon, William C.
    Myint, Wazo
    Hou, Shurong
    Kanai, Tapan
    Schiffer, Celia A.
    Matsuo, Hiroshi
    FASEB JOURNAL, 2019, 33
  • [3] APOBEC3G cytidine deaminase association with coronavirus nucleocapsid protein
    Wang, Shui-Mei
    Wang, Chin-Tien
    VIROLOGY, 2009, 388 (01) : 112 - 120
  • [4] Functional analysis of the two cytidine deaminase domains in APOBEC3G
    Li, Xiaoyu
    Ma, Jing
    Zhang, Quan
    Zhou, Jinming
    Yin, Xiao
    Zhai, Congjie
    You, Xuefu
    Yu, Liyan
    Guo, Fei
    Zhao, Lixun
    Li, Zelin
    Zeng, Yi
    Cen, Shan
    VIROLOGY, 2011, 414 (02) : 130 - 136
  • [5] APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses
    Esnault, C
    Heidmann, O
    Delebecque, F
    Dewannieux, M
    Ribet, D
    Hance, AJ
    Heidmann, T
    Schwartz, O
    NATURE, 2005, 433 (7024) : 430 - 433
  • [6] APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses
    Cécile Esnault
    Odile Heidmann
    Frédéric Delebecque
    Marie Dewannieux
    David Ribet
    Allan J. Hance
    Thierry Heidmann
    Olivier Schwartz
    Nature, 2005, 433 : 430 - 433
  • [7] Transcriptional regulation of APOBEC3G, a cytidine deaminase that hypermutates human immunodeficiency virus
    Rose, KM
    Marin, M
    Kozak, SL
    Kabat, D
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (40) : 41744 - 41749
  • [8] Antiviral function of APOBEC3G can be dissociated from cytidine deaminase activity
    Newman, ENC
    Holmes, RK
    Craig, HM
    Klein, KC
    Lingappa, JR
    Malim, MH
    Sheehy, AM
    CURRENT BIOLOGY, 2005, 15 (02) : 166 - 170
  • [9] Distinct Mutagenic Activity of APOBEC3G Cytidine Deaminase Identified in Bladder Cancer
    Caswell, Deborah
    Swanton, Charles
    CANCER RESEARCH, 2023, 83 (04) : 487 - 488
  • [10] Direct evidence that RNA inhibits APOBEC3G ssDNA cytidine deaminase activity
    McDougall, William M.
    Smith, Harold C.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 412 (04) : 612 - 617
12345