Relationship between serum uric acid in early pregnancy and gestational diabetes mellitus: a prospective cohort study

The levels of serum uric acid (UA) and creatinine in the first trimester of pregnant women were significantly lower than healthy non-pregnant women, probably because of the increase of glomerular filtration.Serum UA concentration in the first trimester was significantly higher in women with gestational diabetes mellitus (GDM) than in women with normal glucose tolerance (NGT). The association of serum UA in the first trimester and GDM were observed when serum UA was above 240 μmol/l, and the association was stronger in women aged over 35 years old and preBMI ≥ 24 kg/m2.To prevent GDM, healthy lifestyle intervention should be taken since early pregnancy to control serum UA concentration, especially in older and heavier pregnant women.