Genetic Linkage and Association Analysis for Loneliness in Dutch Twin and Sibling Pairs Points to a Region on Chromosome 12q23–24

被引：0
|
作者：
Dorret I. Boomsma
John T. Cacioppo
P. Eline Slagboom
Danielle Posthuma
机构：
[1] Vrije Universiteit,Department of Biological Psychology
[2] University of Chicago,Department of Molecular Epidemiology
[3] Leiden University Medical Centre,Department of Biological Psychology
[4] Vrije Universiteit,undefined
来源：
Behavior Genetics | 2006年 / 36卷
关键词：
Association; heritability; linkage; loneliness; ordinal data; QTL; sib-pair;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We obtained evidence from a large study in Dutch twins (N=8387) and siblings (N=2295) that variation in loneliness has a genetic component. The heritability estimate for loneliness, which was assessed as an ordinal trait, was 40% and did not differ between males and females. There were 682 sibling pairs with genotypic (around 400 microsatellite markers) data. We combined phenotypic and genotypic data to carry out a genome scan to localize QTLs for loneliness. One region on chromosome 12q23.3–24.3, showed near suggestive linkage. Genetic association tests within this region revealed significant association (p-value 0.009) with one of the alleles of marker D12S79 and with one of the alleles of neighbouring marker D12S395 (p-value 0.043). We review evidence for linkage in this region for psychiatric disorders and discuss our findings within this context.
引用
收藏
页码：137 / 146
页数：9
相关论文
共 50 条
  • [21] Chromosome 11-q24 region in Tourette syndrome:: Association and linkage disequilibrium study in the French Canadian population
    Díaz-Anzaldúa, A
    Rivière, JB
    Dubé, MP
    Joober, R
    Saint-Onge, J
    Dion, Y
    Lespérance, P
    Richer, F
    Chouinard, S
    Rouleau, GA
    AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2005, 138A (03) : 225 - 228
  • [22] Linkage analysis localises a Kartagener syndrome gene to a 3.5 cM region on chromosome 15q24-25
    Geremek, M
    Zietkiewicz, E
    Diehl, SR
    Alizadeh, BZ
    Wijmenga, C
    Witt, M
    JOURNAL OF MEDICAL GENETICS, 2006, 43 (01)
  • [23] GENETIC-LINKAGE ANALYSIS OF SCHIZOPHRENIA USING CHROMOSOME 11Q13-24 MARKERS IN ISRAELI PEDIGREES
    MULCRONE, J
    WHATLEY, SA
    MARCHBANKS, R
    WILDENAUER, D
    ALTMARK, D
    DAOUD, H
    GUR, E
    EBSTEIN, RP
    LERER, B
    AMERICAN JOURNAL OF MEDICAL GENETICS, 1995, 60 (02): : 103 - 108
  • [24] Genome-wide search for linkage of bipolar affective disorders in a very large pedigree derived from a homogeneous population in Quebec points to a locus of major effect on chromosome 12q23-q24
    Morissette, J
    Villeneuve, A
    Bordeleau, L
    Rochette, D
    Laberge, C
    Gagné, B
    Laprise, C
    Bouchard, G
    Plante, M
    Gobeil, L
    Shink, E
    Weissenbach, J
    Barden, N
    AMERICAN JOURNAL OF MEDICAL GENETICS, 1999, 88 (05): : 567 - 587
  • [25] Genome-wide association study of epilepsy in a Japanese population identified an associated region at chromosome 12q24
    Suzuki, Toshimitsu
    Koike, Yoshinao
    Ashikawa, Kyota
    Otomo, Nao
    Takahashi, Atsushi
    Aoi, Tomomi
    Kamatani, Naoyuki
    Nakamura, Yusuke
    Kubo, Michiaki
    Kamatani, Yoichiro
    Momozawa, Yukihide
    Terao, Chikashi
    Yamakawa, Kazuhiro
    EPILEPSIA, 2021, 62 (06) : 1391 - 1400
  • [26] A SNP within a gene desert on chromosome 11q23-24 partially explains the genetic linkage to BMI in this region in pima indians: Evidence that this SNP regulates gene expression in him
    Traurig, Michael
    Kobes, Sayuk
    Hanson, Rob
    Bogardus, Clifton
    Baier, Leslie
    DIABETES, 2007, 56 : A296 - A296
  • [27] Genetic linkage and association of Fcγ receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus
    Edberg, JC
    Langefeld, CD
    Wu, JM
    Moser, KL
    Kaufman, KM
    Kelly, J
    Bansal, V
    Brown, WM
    Salmon, JE
    Rich, SS
    Harley, JB
    Kimberly, RP
    ARTHRITIS AND RHEUMATISM, 2002, 46 (08): : 2132 - 2140
  • [28] Linkage disequilibrium mapping of bipolar affective disorder at 12q23-q24 provides evidence for association at CUX2 and FLJ32356
    Glaser, B
    Kirov, G
    Green, E
    Craddock, N
    Owen, MJ
    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2005, 132B (01) : 38 - 45
  • [29] LINKAGE ANALYSIS OF CHROMOSOME 22Q12-13 IN A UNITED-KINGDOM ICELANDIC SAMPLE OF 23 MULTIPLEX SCHIZOPHRENIA FAMILIES
    KALSI, G
    BRYNJOLFSSON, J
    BUTLER, R
    SHERRINGTON, R
    CURTIS, D
    SIGMUNDSSON, T
    READ, T
    MURPHY, P
    SHARMA, T
    PETURSSON, H
    GURLING, HMD
    AMERICAN JOURNAL OF MEDICAL GENETICS, 1995, 60 (04): : 298 - 301
  • [30] LINKAGE ANALYSIS BETWEEN MANIC-DEPRESSIVE ILLNESS AND THE REGION ON CHROMOSOME-12Q INVOLVED IN DARIERS-DISEASE
    EWALD, H
    MORS, O
    FLINT, T
    KRUSE, TA
    PSYCHIATRIC GENETICS, 1994, 4 (04) : 195 - 200
12345