A New Antioxidant, Clitocybin A, from the Culture Broth of Clitocybe aurantiaca

被引：0
|
作者：
Young-Hee Kim
Sung-Min Cho
Jin-Won Hyun
In-Ja Ryoo
Soo-Jin Choo
Sangku Lee
Soon-Ja Seok
Jae Sung Hwang
Eui Dong Sohn
Bong-Sik Yun
Ki Hwan Bae
Ick-Dong Yoo
机构：
[1] Functional Metabolomics Research Center,Department of Pharmacy
[2] Korea Research Institute of Bioscience and Biotechnology,undefined
[3] College of Medicine,undefined
[4] Cheju National University,undefined
[5] National Institute of Agricultural Science and Technology,undefined
[6] RDA,undefined
[7] Amorepacific Corporation R&D Center,undefined
[8] Giheung,undefined
[9] Chungnam National University,undefined
来源：
The Journal of Antibiotics | 2008年 / 61卷
关键词：
clitocybin A; antioxidant activity; comet assay;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Clitocybin A (1), a new antioxidant, was isolated from the culture broth of Clitocybe aurantiaca. This compound was purified by solvent extraction, silica gel column chromatography, Sephadex LH-20 column chromatography and preparative HPLC. Its structure was determined as 4,6-dihydroxy-2-ρ-hydroxyphenyl-isoindol-1-one on the basis of the UV, NMR, and MS spectroscopic analysis. The compound 1 showed potent free radical scavenging activity against superoxide, ABTS, and DPPH radicals, and protective effect against cellular DNA damage induced by oxidative stress.
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页码：573 / 576
页数：3
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