A New Antioxidant, Clitocybin A, from the Culture Broth of Clitocybe aurantiaca

被引：0

作者：

Young-Hee Kim

Sung-Min Cho

Jin-Won Hyun

In-Ja Ryoo

Soo-Jin Choo

Sangku Lee

Soon-Ja Seok

Jae Sung Hwang

Eui Dong Sohn

Bong-Sik Yun

Ki Hwan Bae

Ick-Dong Yoo

机构：

[1] Functional Metabolomics Research Center,Department of Pharmacy

[2] Korea Research Institute of Bioscience and Biotechnology,undefined

[3] College of Medicine,undefined

[4] Cheju National University,undefined

[5] National Institute of Agricultural Science and Technology,undefined

[6] RDA,undefined

[7] Amorepacific Corporation R&D Center,undefined

[8] Giheung,undefined

[9] Chungnam National University,undefined

来源：

The Journal of Antibiotics | 2008年 / 61卷

关键词：

clitocybin A; antioxidant activity; comet assay;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Clitocybin A (1), a new antioxidant, was isolated from the culture broth of Clitocybe aurantiaca. This compound was purified by solvent extraction, silica gel column chromatography, Sephadex LH-20 column chromatography and preparative HPLC. Its structure was determined as 4,6-dihydroxy-2-ρ-hydroxyphenyl-isoindol-1-one on the basis of the UV, NMR, and MS spectroscopic analysis. The compound 1 showed potent free radical scavenging activity against superoxide, ABTS, and DPPH radicals, and protective effect against cellular DNA damage induced by oxidative stress.

引用

页码：573 / 576

页数：3

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