Comparative in Vitro Activity of Voriconazole and Itraconazole Against Fluconazole-Susceptible and Fluconazole-Resistant Clinical Isolates of Candida Species from Spain

被引：0
|
作者：
M. Cuenca-Estrella
T. M. Díaz-Guerra
E. Mellado
A. Monzón
J. L. Rodríguez-Tudela
机构：
[1] Unidad de Micologia,
[2] Centro Nacional de Microbiologia,undefined
[3] Instituto de Salud Carlos III,undefined
[4] Ctra. Majadahonda-Pozuelo km 2,undefined
[5] E-28220 Majadahonda,undefined
[6] Madrid,undefined
[7] Spain e-mail: juanl.rodriguez-tudela@isciii.es,undefined
来源：
European Journal of Clinical Microbiology and Infectious Diseases | 1999年 / 18卷
关键词：
Fluconazole; Triazole; Itraconazole; Voriconazole; Azole;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
 The in vitro activity of voriconazole was compared with that of itraconazole against 299 fluconazole-susceptible (MIC≤8 μg/ml) and 130 fluconazole-resistant (MIC≥16 μg/ml) clinical isolates of Candida spp. An adaptation of the National Committee for Clinical Laboratory Standards reference method was employed for determination of MICs. Voriconazole showed more potent activity than either fluconazole and itraconazole, even against some Candidaalbicans, Candidaglabrata, and Candidakrusei isolates resistant to fluconazole. However, for fluconazole-resistant isolates, the MICs of itraconazole and voriconazole were proportionally higher than for fluconazole-susceptible isolates. These data may indicate cross-resistance.
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页码：432 / 435
页数：3
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