Synthesis and antifungal activity of organofluorine derivatives of levorin

被引：0
|
作者：
Belakhov V.V. [1 ]
Shenin Yu.D. [2 ]
Araviisky R.A. [3 ,4 ]
机构：
[1] Department of Chemistry, Technion - Israel Institute of Technology, Haifa
[2] All-Russia Institute for Plant Protection, St. Petersburg
[3] St. Petersburg Medical Academy of Post-Graduate Education, St. Petersburg
[4] Kashkin Research Institute of Medical Mycology, St. Petersburg
来源：
Pharmaceutical Chemistry Journal | 2007年 / 41卷 / 9期
关键词：
Antifungal Activity; Cryptococcus Neoformans; Macrolide Antibiotic; Dermatomycosis; Sporotrichosis;
D O I：
10.1007/s11094-007-0106-2
中图分类号：
学科分类号：
摘要：
Reactions of the polyene macrolide antibiotic levorin with organofluorine alcohols lead to the formation of organofluorine esters. Two organofluorine derivatives of levorin have been synthesized and their physicochemical and biological properties have been studied. These derivatives show high antifungal activity against a large number of test cultures. The acute toxicity (LD 50) of levorin derivatives was about half that of the initial antibiotic. © 2007 Springer Science+Business Media, Inc.
引用
收藏
页码：480 / 482
页数：2
相关论文
共 50 条
  • [21] Synthesis and Antifungal Activity of Chimonanthus praecox Derivatives
    Chen, Jinfeng
    Yang, Yimou
    Zhou, Yujie
    Wei, Yang
    Zhu, Rui
    Zheng, Shaojun
    MOLECULES, 2022, 27 (17):
  • [22] Synthesis and Antifungal Activity of Novel Triazole Derivatives
    Yan, Yongzheng
    Yu, Shichong
    Chai, Xiaoyun
    Hu, Honggang
    Wu, Qiuye
    ARCHIVES OF PHARMACAL RESEARCH, 2011, 34 (10) : 1649 - 1656
  • [23] Synthesis and antifungal activity of novel triazole derivatives
    Sun Qing-Yan
    Cao Yong-Bing
    Xu Jian-Ming
    Zhang Wan-Nian
    Zhang Jun
    Wu Qiu-Ye
    Zhang Da-Zhi
    Jiang Yuan-Ying
    CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2007, 28 (09): : 1707 - 1709
  • [24] Synthesis and antifungal activity of novel triazole derivatives
    Yongzheng Yan
    Shichong Yu
    Xiaoyun Chai
    Honggang Hu
    Qiuye Wu
    Archives of Pharmacal Research, 2011, 34 : 1649 - 1656
  • [25] Design,synthesis and antifungal activity of carbazole derivatives
    Shi-Ping Zhu
    Wen-Ya Wang
    Kun Fang
    Zheng-Gang Li
    Guo-Qiang Dong
    Zhen-Yuan Miao
    Jian-Zhong Yao
    Wan-Nian Zhang
    Chun-Quan Sheng
    ChineseChemicalLetters, 2014, 25 (02) : 229 - 233
  • [26] Synthesis of Isosteric Triterpenoid Derivatives and Antifungal Activity
    Innocente, Adrine
    Casanova, Bruna B.
    Klein, Fernanda
    Lana, Aline D.
    Pereira, Dariane
    Muniz, Mauro N.
    Sonnet, Pascal
    Gosmann, Grace
    Fuentefria, Alexandre M.
    Gnoatto, Simone C. B.
    CHEMICAL BIOLOGY & DRUG DESIGN, 2014, 83 (03) : 344 - 349
  • [27] Synthesis and Antifungal Activity of Khusinol and its Derivatives
    K. K. Urvashi
    Ramandeep Chahal
    Chemistry of Natural Compounds, 2018, 54 : 898 - 902
  • [28] SYNTHESIS AND ANTIFUNGAL ACTIVITY OF KHUSINOL AND ITS DERIVATIVES
    Urvashi
    Chahal, K. K.
    Kaur, Ramandeep
    CHEMISTRY OF NATURAL COMPOUNDS, 2018, 54 (05) : 898 - 902
  • [29] Synthesis and Antifungal Activity of Some Thiazole Derivatives
    Song, Ya-Li
    Liu, Xiao-Ming
    Yang, Ning
    Yang, Geng-Liang
    ASIAN JOURNAL OF CHEMISTRY, 2013, 25 (04) : 1849 - 1852
  • [30] Studies on the synthesis and antifungal activity of thiochromanone derivatives
    Fang, L
    Guo, C
    Zhang, QB
    CHINESE CHEMICAL LETTERS, 1997, 8 (11) : 939 - 942
12345