A Study of Haloperidol Inclusion Complexes with β-Cyclodextrin Using Phase Solubility, NMR Spectroscopy and Molecular Modeling Techniques

被引：0
|
作者：
Mahmoud M. Al Omari
Mohammad B. Zughul
J. Eric D. Davies
Adnan A. Badwan
机构：
[1] The Jordanian Pharmaceutical Manufacturing Company,Department of Chemistry
[2] University of Jordan,Department of Environmental Science
[3] Lancaster University,undefined
来源：
Journal of Solution Chemistry | 2009年 / 38卷
关键词：
Haloperidol; Aqueous p; Cyclodextrin; Hydrophobic effect; H-NMR; Molecular modeling;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Guest-host interactions of haloperidol (Halo) with β-cyclodextrin (β-CD) have been investigated using several techniques including phase solubility diagrams (PSD), proton nuclear magnetic resonance (1H-NMR), X-ray powder diffractometry (XRPD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and molecular mechanical modeling (MM+).
引用
收藏
页码：669 / 683
页数：14
相关论文
共 50 条
  • [41] Preparation, characterization, and molecular modeling of sesamol/β-cyclodextrin derivatives inclusion complexes
    Han, Ping
    Zhong, Yuanyuan
    An, Ning
    Lu, Shiling
    Wang, Qingling
    Dong, Juan
    JOURNAL OF MOLECULAR LIQUIDS, 2021, 339
  • [42] MOLECULAR MODELING OF INCLUSION COMPLEXES OF PER-PENTYL-BETA-CYCLODEXTRIN
    CWIK, MJ
    FITZLOFF, JF
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1993, 206 : 12 - ANYL
  • [43] Inclusion Complexes of Sunscreen Agents with β-Cyclodextrin: Spectroscopic and Molecular Modeling Studies
    Al-Rawashdeh, Nathir A. F.
    Al-Sadeh, Khaled S.
    Al-Bitar, Mohammad Bassam
    JOURNAL OF SPECTROSCOPY, 2013, 2013
  • [44] Inclusion complexes of N-sulfamoyloxazolidinones with β-cyclodextrin: A molecular modeling approach
    Dinar, Karim
    Sahra, Khalil
    Seridi, Achour
    Kadri, Mekki
    CHEMICAL PHYSICS LETTERS, 2014, 595 : 113 - 120
  • [45] Structural Characterization of Inclusion Complex of Stigmasterol with Alpha-Cyclodextrin using Spectroscopy and Molecular Modeling
    Francy, Kuruz
    Kumari, Johnson Prema
    Roselet, Simon Lizy
    BIOMEDICAL AND BIOTECHNOLOGY RESEARCH JOURNAL, 2022, 6 (01): : 54 - 59
  • [46] Molecular modeling study of β- and γ-cyclodextrin complexes with miconazole
    Piel, G
    Dive, G
    Evrard, B
    Van Hees, T
    de Hassonville, SH
    Delattre, L
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2001, 13 (03) : 271 - 279
  • [47] NMR diffusion coefficient study of steroid-cyclodextrin inclusion complexes
    Cameron, KS
    Fielding, L
    MAGNETIC RESONANCE IN CHEMISTRY, 2002, 40 : S106 - S109
  • [48] NMR spectroscopic study of inclusion complexes of cetirizine dihydrochloride and β-cyclodextrin in solution
    Ali, Syed Mashhood
    Upadhyay, Santosh Kumar
    Maheshwari, Arti
    SPECTROSCOPY-AN INTERNATIONAL JOURNAL, 2007, 21 (03): : 177 - 182
  • [49] NMR study of the solution structures of the inclusion complexes of β-cyclodextrin with (+)-catechin and (-)-epicatechin
    Ishizu, T
    Kintsu, K
    Yamamoto, H
    JOURNAL OF PHYSICAL CHEMISTRY B, 1999, 103 (42): : 8992 - 8997
  • [50] NMR spectroscopic study of cyclodextrin inclusion complexes with A-007 prodrugs
    Sagiraju, Sarada
    Jursic, Branko S.
    CARBOHYDRATE RESEARCH, 2008, 343 (07) : 1180 - 1190
12345