Role of EGFL7/EGFR-signaling pathway in migration and invasion of growth hormone-producing pituitary adenomas

被引:0
|
作者
Qian Liu
Junwen Zhang
Hua Gao
Taoyang Yuan
Jie Kang
Lu Jin
Songbai Gui
Yazhuo Zhang
机构
[1] Capital Medical University,Beijing Neurosurgical Institute
[2] Capital Medical University,Beijing Tiantan Hospital
[3] Capital Medical University,Key Laboratory of Central Nervous System Injury Research, Beijing Institute for Brain Disorders Brain Tumor Center, China National Clinical Research Center for Neurological Diseases
来源
Science China Life Sciences | 2018年 / 61卷
关键词
EGFL7; EGFR; growth hormone-producing pituitary adenomas (GHPA); invasion; tumorigenesis;
D O I
暂无
中图分类号
学科分类号
摘要
Currently, the primary therapeutic strategy for most growth hormone-producing pituitary adenomas (GHPA) is surgery. Due to the invasiveness of GHPA, high recurrence has limited the benefit of complete adenoma removal surgery. Epidermal growth factor-like domain 7 (EGFL7) is a secreted factor implicated in tumor angiogenesis, growth, invasiveness and metastasis in GHPA. Herein, we observed that the expression level of EGFL7 and p-EGFR in invasive GHPA was much higher than that of non-invasive GHPA. The overexpression of EGFL7 was positively correlated with activation of EGFR (p-EGFR). Noticeably, EGFL7 knockdown significantly inhibited activation of EGFR signaling cascades, including p-ERGR, p-AKT and p-ERK. Further studies showed that EGFL7 knockdown or pharmacological inhibition of EGFR-pathway, using EGFR inhibitor Tyrphostin AG-1478, significantly suppressed migration and invasion of GH3 and GT1-1 cells. In summary, our findings suggest that EGFL7 is a key factor for regulation of EGFR signaling pathway and plays an important role in migration and invasion of invasive GHPA.
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页码:893 / 901
页数:8
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