Comparison of three methods for pharmacokinetic screening in rats using LC-MS-MS

被引：0
|
作者：
S. Briem
E. Eklund
G. Williams
J. Brunvoll
机构：
[1] Department of DMPK Research AstraZeneca R&D Södertälje,Micromass AB Sweden
[2] University of Tromsø,Institute of Pharmacy
[3] University of Tromsø,undefined
来源：
Chromatographia | 2002年 / 55卷
关键词：
Liquid chromatography-mass spectrometry; Sample preparation; Ian suppression; Pharmacokinetic screening;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The influence of sample preparation on ion suppression is studied using the model compounds ropivacaine and 3OH-ropivacaine. Three sample preparation techniques are assessed: Solid Phase Extraction (SPE), Direct Dilution and Protein Precipitation. Although requiring more method development and being more time-consuming than the two alternative preparation techiques, SPE had a greater impact on reducing ion suppression.
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页码：S35 / S39
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