Synthesis of 3-Aminopyridin-2(1H)-Ones and 1H-Pyrido[2,3-b][1,4]Oxazin-2(3H)-Ones

被引：0
|
作者：
A. S. Fisyuk
I. V. Kulakov
D. S. Goncharov
O. S. Nikitina
Y. P. Bogza
A. L. Shatsauskas
机构：
[1] Omsk F. M. Dostoevsky State University,
[2] Omsk State Technical University,undefined
来源：
Chemistry of Heterocyclic Compounds | 2014年 / 50卷
关键词：
3-aminopyridin-2(1; )-ones; Enamino ketones; -(3-oxoalkenyl)amides; Chloroacetamides; Intramolecular cyclization;
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中图分类号：
学科分类号：
摘要：
The interaction of 1,3-diketones with chloroacetamide produced N-(3-oxoalkenyl)chloroacetamides. Heating of N-(3-oxoalkenyl)chloroacetamides with an excess of pyridine in ethanol or butanol led to the formation of pyridin-2(1Н)-ones, substituted with a pyridine ring at position 3. The reactions of these compounds with hydrazine hydrate produced 3-aminopyridin-2(1Н)-ones. The synthesis of 1H-pyrido[2,3-b][1, 4]oxazin-2(3H)-ones was accomplished by a reaction of 3-aminopyridin-2(1Н)-ones with chloroacetyl chloride.
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页码：217 / 224
页数：7
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