Quantification of Cathinone Analogues without Reference Standard Using 1H Quantitative NMR

被引:0
|
作者
Yuxin Zhao
Bo Wu
Zhendong Hua
Peng Xu
Hui Xu
Wenbin Shen
Bin Di
Youmei Wang
Mengxiang Su
机构
[1] China Pharmaceutical University,School of Pharmacy
[2] China National Narcotics Control Commission,China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control
[3] Nanjing Municipal Public Security Bureau,The Narcotic Control Division
[4] Ministry of Public Security,Key Laboratory of Drug Monitoring and Control, Drug Intelligence and Forensic Center
[5] China Pharmaceutical University,Center for Instrumental Analysis
来源
Analytical Sciences | 2021年 / 37卷
关键词
assay; synthetic cathinones; structure identification; quantitation;
D O I
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中图分类号
学科分类号
摘要
Synthetic cathinones are a type of new psychoactive substances (NPS) that have been seriously abused. Owing to the rapid variation in their structures, the absence of reference standards poses a challenge in quantitative investigations. In this study, a 1H quantitative nuclear magnetic resonance (1H qNMR) method was established using maleic acid as the internal standard and the shared signal (i.e., the methylidyne hydrogen) on the parent synthetic cathinones structure as the quantitative peak. Taking 3-methoxy-2-(methylamino)-1-(4-methylphenyl)propan-1-one (mexedrone) as an example, this study optimized the acquisition parameters and conducted method validation, including an evaluation of the specificity, linearity, accuracy, precision, and robustness. Using this 1H qNMR method, the contents of mexedrone and its analogues, including 1-(3-chlorophenyl)-2-(ethylamino)-propan-1-one (3-CEC), 4-chloro-α-pyrroli-dinopropiophenone (4-Cl-α- PVP), 1-(3,4-methylenedioxy-phenyl)-2-propylamino-propan-1-one (propylone), and methcathinone, were obtained. The obtained results showed that the method was accurate, rapid, versatile, and can be used to address the qualitative and quantitative issues related to similar substances.
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页码:1578 / 1582
页数:4
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