It's Electric: When Technology Gives a Boost to Stem Cell Science

被引：13
|
作者：
Lee A.P. [1 ]
Aghaamoo M. [2 ]
Adams T.N.G. [3 ]
Flanagan L.A. [4 ]
机构：
[1] Departments of Biomedical Engineering and Mechanical & Aerospace Engineering, NSF I/UCRC, Center for Advanced Design & Manufacturing of Integrated Microfluidics (CADMIM), Biomolecular Microsystems and Nano Transducers (BioMiNT) Lab, 3120 Natural Sciences I
[2] Department of Biomedical Engineering, Biomolecular Microsystems and Nano Transducers (BioMiNT) Lab, 3130 Engineering Hall, Irvine, 92697-2715, CA
[3] Departments of Biomedical Engineering and Neurology, Sue & Bill Gross Stem Cell Research Center, University of California, Irvine, 3200 Gross Hall, 845 Health Sciences Road, Irvine, 92697-1705, CA
[4] Departments of Neurology, Biomedical Engineering and Anatomy & Neurobiology, Sue & Bill Gross Stem Cell Research Center, University of California, Irvine, 3030 Gross Hall, 845 Health Sciences Road, Irvine, 92697-1705, CA
来源：
Current Stem Cell Reports | 2018年 / 4卷 / 2期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
Analysis; Dielectrophoresis; Impedance; Membrane capacitance; Separation; Stem cell;
D O I：
10.1007/s40778-018-0124-x
中图分类号：
学科分类号：
摘要：
Purpose of Review: Advanced technologies can aid discoveries in stem cell science in surprising ways. The application of electrokinetic techniques, which use electric fields to interrogate or separate cells, to the study of stem cells has yielded important insights into stem cell function. These techniques probe inherent cell properties, obviating the need for cell-type specific labels. Recent Findings: Analysis of a variety of stem cell types including hematopoietic, mesenchymal and adipose-derived, neural, and pluripotent stem cells by electrokinetic techniques has revealed fate-specific signatures of cells. Distinct inherent cell properties are sufficient for their label-free enrichment without causing cell damage or toxicity. Summary: The successful application of label-free techniques to the analysis and sorting of stem cells open new avenues for exploring the basic biology of stem cells and optimizing their use in regenerative medicine applications. © 2018, Springer International Publishing AG, part of Springer Nature.
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页码：116 / 126
页数：10
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