Micellar Electrokinetic Chromatography and Mass Spectrometry Studies of Mildronate Stability in Aqueous Solutions

被引：0
|
作者：
M. V. Gavrilin
Yu. V. Mudretsova
机构：
[1] Rostov State Medical University,Pyatigorsk State Medico
[2] Division of Volgograd State Medical University,Pharmaceutical Institute
来源：
Pharmaceutical Chemistry Journal | 2014年 / 48卷
关键词：
mildronate; stability; micellar electrokinetic chromatography; mass spectrometry;
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学科分类号：
摘要：
Mildronate decomposition kinetics in acidic solution were studied using micellar electrokinetic chromatography with indirect detection and mass spectrometry in positive-ion mode. It was found that mildronate was demethylated stepwise in acidic solution to form 3-(2-methylhydrazino)propionic acid and 3-hydrazinopropionic acid. The proposed quantitative determination procedure for mildronate by micellar electrokinetic chromatography with indirect detection enabled quantitative determination in the presence of the destruction products.
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页码：139 / 142
页数：3
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