Pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor ximelagatran co-administered with different classes of antibiotics in healthy volunteers

被引:0
|
作者
Hassan Dorani
Kajs-Marie Schützer
Troy C. Sarich
Ulrika Wall
Ulrika Logren
Lis Ohlsson
Ulf G. Eriksson
机构
[1] AstraZeneca Research and Development,Experimental Medicine
[2] AstraZeneca LP,undefined
[3] Johnson and Johnson Pharmaceutical Research and Development,undefined
关键词
Ximelagatran; Melagatran; Antibiotic interactions; Oral direct thrombin inhibitors; P-glycoprotein pump (p-GP);
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:571 / 581
页数:10
相关论文
共 50 条
  • [41] A comparison of the pharmacokinetics and pharmacodynamics of inhaled insulin administered as different strength solutions to healthy volunteers
    Farr, S
    McElduff, A
    Ward, E
    Okumu, F
    Mather, L
    Gonda, I
    Rubsamen, R
    DIABETES, 1998, 47 : A61 - A61
  • [42] Inhibition of thrombin generation by the oral direct thrombin inhibitor ximelagatran in shed blood from healthy male subjects
    Sarich, TC
    Eriksson, UG
    Mattsson, C
    Wolzt, M
    Frison, L
    Fager, G
    Gustafsson, D
    THROMBOSIS AND HAEMOSTASIS, 2002, 87 (02) : 300 - 305
  • [43] ASSESSMENT OF THE PHARMACOKINETICS OF CO-ADMINISTERED METFORMIN AND LOBEGLITAZONE, A NOVEL THIAZOLIDINEDIONE ANTIHYPERGLYCEMIC AGENT, IN HEALTHY VOLUNTEERS
    Shin, D.
    Kim, T.
    Jeon, H.
    Yoon, S.
    Cho, J.
    Yu, K.
    Shin, S.
    Jang, I.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2011, 89 : S90 - S90
  • [44] The Pharmacokinetics, Pharmacodynamics, and Safety of Baricitinib, an Oral JAK 1/2 Inhibitor, in Healthy Volunteers
    Shi, Jack G.
    Chen, Xuejun
    Lee, Fiona
    Emm, Thomas
    Scherle, Peggy A.
    Lo, Yvonne
    Punwani, Naresh
    Williams, William V.
    Yeleswaram, Swamy
    JOURNAL OF CLINICAL PHARMACOLOGY, 2014, 54 (12): : 1354 - 1361
  • [45] Pharmacokinetics and tolerability of voriconazole and a combination oral contraceptive co-administered in healthy female subjects
    Andrews, Emma
    Damle, Bharat D.
    Fang, Annie
    Foster, Grover
    Crownover, Penelope
    LaBadie, Robert
    Glue, Paul
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2008, 65 (04) : 531 - 539
  • [46] Aliskiren, an oral direct renin inhibitor, has no effect on the pharmacokinetics or pharmacodynamics of a single dose of acenocoumarol in healthy volunteers.
    Huang, H. A.
    Vaidyanathan, S.
    Yeh, C.
    Dieterich, H. A.
    Dole, W. P.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2008, 83 : S59 - S60
  • [47] PHARMACOKINETICS OF AZD0837, A NOVEL DIRECT THROMBIN INHIBITOR, AFTER ORAL AND INTRAVENOUS ADMINISTRATION TO HEALTHY MALE VOLUNTEERS
    Johansson, S.
    Cullberg, M.
    Ekdahl, A.
    Wahlander, K.
    Duner, K.
    Eriksson, U. G.
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2009, 105 : 105 - 105
  • [48] Steady-State Pharmacokinetics of Darunavir/Ritonavir and Pitavastatin when Co-administered to Healthy Adult Volunteers
    Christine Y. Yu
    Stuart E. Campbell
    Craig A. Sponseller
    David S. Small
    Matthew M. Medlock
    Roger E. Morgan
    Clinical Drug Investigation, 2014, 34 : 475 - 482
  • [49] Steady-State Pharmacokinetics of Darunavir/Ritonavir and Pitavastatin when Co-administered to Healthy Adult Volunteers
    Yu, Christine Y.
    Campbell, Stuart E.
    Sponseller, Craig A.
    Small, David S.
    Medlock, Matthew M.
    Morgan, Roger E.
    CLINICAL DRUG INVESTIGATION, 2014, 34 (07) : 475 - 482
  • [50] Pharmacokinetics of the HIV integrase inhibitor S/GSK1349572 co-administered with acid-reducing agents and multivitamins in healthy volunteers
    Patel, Parul
    Song, Ivy
    Borland, Julie
    Patel, Apurva
    Lou, Yu
    Chen, Shuguang
    Wajima, Toshihiro
    Peppercorn, Amanda
    Min, Sherene S.
    Piscitelli, Stephen C.
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2011, 66 (07) : 1567 - 1572