Metabolism-Associated Markers and Childhood Autism Rating Scales (CARS) as a Measure of Autism Severity

被引:0
|
作者
Afaf El-Ansary
Geir Bjørklund
Asma M. Khemakhem
Laila Al-Ayadhi
Salvatore Chirumbolo
Abir Ben Bacha
机构
[1] King Saud University,Autism Research and Treatment Center
[2] King Saud University,Shaik AL
[3] King Saud University,Amodi Autism Research Chair
[4] Council for Nutritional and Environmental Medicine,Central Laboratory
[5] University of Sfax,Laboratory of Plant Biotechnology Applied to Crop Improvement, Faculty of Science of Sfax
[6] King Saud University,Department of Physiology, Faculty of Medicine
[7] University of Verona,Department of Neurological and Movement Sciences
[8] King Saud University,Biochemistry Department, Science College
来源
Journal of Molecular Neuroscience | 2018年 / 65卷
关键词
Autism; Mitochondria; Energy metabolism; MRCC-I/caspase-7; GSH/GST; MRCC-I/COQ10;
D O I
暂无
中图分类号
学科分类号
摘要
Autism spectrum disorder (ASD) is a neuro-behavioral syndrome with a broad spectrum of different mechanisms and etiologies that are caused by abnormal brain development. To date, no highly reliable and effective diagnostic biomarker to assess ASD is available so far. The present study investigated the predictivity potential of some suggested markers in ASD diagnosis focusing onto the relative ratios of several plasma biomarkers of electron transport chain function, and mitochondrial metabolism in 41 patients with ASD evaluated for behavior deficits measured using Childhood Autism Rating Scales (CARS). The control matched for further 41 healthy subjects. The relation of these relative ratios to ASD severity was also examined, as well as their ability to distinguish ASD children from neurotypical children. All predictive ratios were found to be markedly altered and correlated in ASD patients. However, no ratio was connected with autism severity. Interestingly, MRCC-I/caspase-7, GSH/GST, and MRCC-I/COQ10 were the most distinctive relative ratios between neurotypical controls and ASD patients and may thereby be useful biomarkers for early diagnosis of ASD. Overall, this investigation proves that relative ratios of numerous mitochondrial biomarkers might be predictive and efficient to differentiate between neurotypical children and ASD.
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页码:265 / 276
页数:11
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