Simvastatin suppresses vascular inflammation and atherosclerosis in ApoE−/− mice by downregulating the HMGB1-RAGE axis

被引:0
|
作者
Ming Liu
Ying Yu
Hong Jiang
Lei Zhang
Pei-pei Zhang
Peng Yu
Jian-guo Jia
Rui-zhen Chen
Yun-zeng Zou
Jun-bo Ge
机构
[1] Shanghai Institute of Cardiovascular Diseases,
[2] Zhongshan Hospital,undefined
[3] Shanghai Medical College,undefined
[4] Fudan University,undefined
[5] Ministry of Public Health Key Laboratory of Heart Diseases,undefined
[6] Zhongshan Hospital,undefined
[7] Shanghai Medical College,undefined
[8] Fudan University,undefined
来源
Acta Pharmacologica Sinica | 2013年 / 34卷
关键词
atherosclerosis; inflammation; simvastatin; ApoE; mice; human umbilical vein endothelial cells (HUVECs); aortic sinus; HMGB1; RAGE; VCAM-1; MCP-1; macrophages;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:830 / 836
页数:6
相关论文
共 50 条
  • [31] Inhibition of HMGB1/RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists suppresses inflammation
    Huan Yang
    Hui Liu
    Qiong Zeng
    Gavin H. Imperato
    Meghan E. Addorisio
    Jianhua Li
    Mingzhu He
    Kai Fan Cheng
    Yousef Al-Abed
    Helena E. Harris
    Sangeeta S. Chavan
    Ulf Andersson
    Kevin J. Tracey
    Molecular Medicine, 2019, 25
  • [32] Haploinsufficiency Of Sam68 Attenuates Vascular Inflammation And Atherosclerosis In Apoe-deficient Mice
    Han, Shuling
    Zhou, Junlan
    Qin, Gangjian
    CIRCULATION RESEARCH, 2014, 115
  • [33] HMGB1-RAGE Axis Makes No Contribution to Cardiac Remodeling Induced by Pressure-Overload (vol 11, e0158514, 2016)
    Lin, H.
    Shen, L.
    Zhang, X.
    Xie, J.
    Hao, H.
    Zhang, Y.
    PLOS ONE, 2016, 11 (12):
  • [34] Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury
    Hong Fan
    Hai-Bin Tang
    Zhe Chen
    Hu-Qing Wang
    Lei Zhang
    Yu Jiang
    Tao Li
    Cai-Feng Yang
    Xiao-Ya Wang
    Xia Li
    Sheng-Xi Wu
    Gui-Lian Zhang
    Journal of Neuroinflammation, 17
  • [35] Blockade of receptor for AGE (RAGE) suppresses vascular inflammation and hypercoagulability in apo E null mice with type 1 diabetes.
    Kislinger, TR
    Tanji, N
    Qu, W
    Goova, MT
    Wendt, TM
    Lu, Y
    Bucciarelli, LG
    Hofmann, MA
    Ferran, LA
    Pischetsrieder, M
    Stern, DM
    Schmidt, AM
    CIRCULATION, 2000, 102 (18) : 41 - 41
  • [36] Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury
    Fan, Hong
    Tang, Hai-Bin
    Chen, Zhe
    Wang, Hu-Qing
    Zhang, Lei
    Jiang, Yu
    Li, Tao
    Yang, Cai-Feng
    Wang, Xiao-Ya
    Li, Xia
    Wu, Sheng-Xi
    Zhang, Gui-Lian
    JOURNAL OF NEUROINFLAMMATION, 2020, 17 (01)
  • [37] HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease
    Chandrashekaran, Varun
    Seth, Ratanesh K.
    Dattaroy, Diptadip
    Alhasson, Firas
    Ziolenka, Jacek
    Carson, James
    Berger, Franklin G.
    Kalyanaraman, Balaramari
    Diehl, Anna Mae
    Chatterjee, Saurabh
    REDOX BIOLOGY, 2017, 13 : 8 - 19
  • [38] Synthesized HMGB1 peptide attenuates liver inflammation and suppresses fibrosis in mice
    Nojiri, Shunsuke
    Tsuchiya, Atsunori
    Natsui, Kazuki
    Takeuchi, Suguru
    Watanabe, Takayuki
    Kojima, Yuichi
    Watanabe, Yusuke
    Kamimura, Hiroteru
    Ogawa, Masahiro
    Motegi, Satoko
    Iwasawa, Takahiro
    Sato, Takeki
    Kumagai, Masaru
    Ishii, Yui
    Kitayama, Tomomi
    Li, Yu-Tung
    Ouchi, Yuya
    Shimbo, Takashi
    Takamura, Masaaki
    Tamai, Katsuto
    Terai, Shuji
    INFLAMMATION AND REGENERATION, 2021, 41 (01)
  • [39] Synthesized HMGB1 peptide attenuates liver inflammation and suppresses fibrosis in mice
    Shunsuke Nojiri
    Atsunori Tsuchiya
    Kazuki Natsui
    Suguru Takeuchi
    Takayuki Watanabe
    Yuichi Kojima
    Yusuke Watanabe
    Hiroteru Kamimura
    Masahiro Ogawa
    Satoko Motegi
    Takahiro Iwasawa
    Takeki Sato
    Masaru Kumagai
    Yui Ishii
    Tomomi Kitayama
    Yu-Tung Li
    Yuya Ouchi
    Takashi Shimbo
    Masaaki Takamura
    Katsuto Tamai
    Shuji Terai
    Inflammation and Regeneration, 41
  • [40] Dietary ellagic acid suppresses atherosclerotic lesion formation and vascular inflammation in apoE-deficient mice
    Park, Sin-Hye
    Kang, Young-Hee
    FASEB JOURNAL, 2013, 27