Synthesis and fungicidal activity of alkyl(aryl)-substituted 1,3,4-thiadiazolidines

3,3'-Methanediylbis(4-methyl-1,3,4-thiadiazolidine) has been obtained through the cyclothio-methylation of methylhydrazine, formaldehyde, and H2S. A series of 2,5-dialkyl(aryl)-3-phenyl(benzyl)-1,3,4-thiadiazolidines has been synthesized through cyclothiomethylation of phenyl(benzyl)hydrazines with aliphatic and aromatic aldehydes and H2S. The fungicidal activity of 2,5-dimethyl-3-phenyl-1,3,4-thia-diazolidine relative to Bipolaris sorokiniana and Fusarium oxysporum has been observed, so as for the water-soluble adduct of methyl iodide and 2,5-dimethyl-3-phenyl-1,3,4-thiadiazolidine relative to Bipolaris sorokiniana.