Post-transplant Lymphoproliferative Disorder (PTLD): Infection, Cancer?

被引：0
|
作者：
Voorhees T.J. [1 ]
Baiocchi R.A. [1 ,2 ]
机构：
[1] Department of Internal Medicine, Division of Hematology, Ohio State University College of Medicine, 460 West 10th Avenue, Columbus, 43210, OH
[2] Division of Hematology, The Ohio State University, 320 West 10th Avenue, Columbus, 43210, OH
来源：
Current Transplantation Reports | 2016年 / 3卷 / 2期
关键词：
EBV; EBV oncogenesis; EBV transformation; Post-transplant lymphoproliferative disorder;
D O I：
10.1007/s40472-016-0102-0
中图分类号：
学科分类号：
摘要：
Post-transplant lymphoproliferative disorder encompasses a broad spectrum of lymphoid disorders that occur in immune-suppressed patients following solid or hematopoietic stem cell transplantation. The Epstein-Barr virus (EBV) is an oncogenic virus capable of transforming B lymphocytes and is associated with the pathogenesis of multiple benign and malignant lymphoproliferative disorders, including PTLD. This review outlines current knowledge of EBV pathogenesis, its role in B cell immortalization, transformation, and as an etiologic agent in lymphoproliferative disorders in immune-suppressed patients following transplantation. Here, we provide discussion incorporating infectious disease and medical oncology aspects. © 2016, Springer International Publishing AG.
引用
收藏
页码：145 / 153
页数：8
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